Timothy Palzkill
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Explore the profile of Timothy Palzkill including associated specialties, affiliations and a list of published articles.
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134
Citations
2879
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Recent Articles
1.
Pham S, Zhao B, Neetu N, Sankaran B, Patil K, Ramani S, et al.
J Virol
. 2025 Jan;
99(2):e0175724.
PMID: 39873493
Importance: Human noroviruses are a significant cause of sporadic and epidemic gastroenteritis worldwide. There are no vaccines or antiviral drugs currently available to treat infections. Our work elucidates the structural...
2.
Prasad B, Atmar R, Ramani S, Palzkill T, Song Y, Crawford S, et al.
Nat Rev Microbiol
. 2025 Jan;
PMID: 39824927
Human noroviruses (HuNoVs) are the leading cause of acute gastroenteritis worldwide in all age groups and cause significant disease and economic burden globally. To date, no approved vaccines or antiviral...
3.
Pham S, Zhao B, Neetu N, Sankaran B, Patil K, Ramani S, et al.
bioRxiv
. 2024 Sep;
PMID: 39345439
Human norovirus (HuNoV) infection is a global health and economic burden. Currently, there are no licensed HuNoV vaccines or antiviral drugs available. The protease encoded by the HuNoV genome plays...
4.
Tang S, Fults A, Boyd S, Gattu N, Tran K, Fan J, et al.
Org Lett
. 2024 Mar;
26(17):3493-3497.
PMID: 38506470
The morpholine heterocycle is a structural unit found in many bioactive compounds and FDA-approved drugs, but the generation of more complex C-functionalized morpholine derivatives remains considerably underexplored. Using systematic chemical...
5.
Judge A, Sankaran B, Hu L, Palaniappan M, Birgy A, Prasad B, et al.
Proc Natl Acad Sci U S A
. 2024 Mar;
121(12):e2313513121.
PMID: 38483989
Cooperative interactions between amino acids are critical for protein function. A genetic reflection of cooperativity is epistasis, which is when a change in the amino acid at one position changes...
6.
Birgy A, Nnabuife C, Palzkill T
Antimicrob Agents Chemother
. 2024 Jan;
68(3):e0110823.
PMID: 38259088
carbapenemase (KPC) variants have been described that confer resistance to both ceftazidime-avibactam and cefiderocol. Of these, KPC-33 and KPC-31 are D179Y-containing variants derived from KPC-2 and KPC-3, respectively. To better...
7.
Park S, Fan J, Chamakuri S, Palaniappan M, Sharma K, Qin X, et al.
J Med Chem
. 2023 Dec;
67(1):620-642.
PMID: 38117688
β-Lactamase enzymes hydrolyze and thereby provide bacterial resistance to the important β-lactam class of antibiotics. The OXA-48 and NDM-1 β-lactamases cause resistance to the last-resort β-lactams, carbapenems, leading to a...
8.
Sun Z, Lin H, Hu L, Neetu N, Sankaran B, Wang J, et al.
J Biol Chem
. 2023 Nov;
300(1):105493.
PMID: 38000656
Klebsiella pneumoniae carbapenemase 2 (KPC-2) is an important source of drug resistance as it can hydrolyze and inactivate virtually all β-lactam antibiotics. KPC-2 is potently inhibited by avibactam via formation...
9.
Jimmidi R, Chamakuri S, Lu S, Ucisik M, Chen P, Bohren K, et al.
Commun Chem
. 2023 Aug;
6(1):164.
PMID: 37542196
The development of SARS-CoV-2 main protease (M) inhibitors for the treatment of COVID-19 has mostly benefitted from X-ray structures and preexisting knowledge of inhibitors; however, an efficient method to generate...
10.
Materon I, Palzkill T
Curr Opin Struct Biol
. 2023 Jul;
82:102647.
PMID: 37399693
Polymyxins, a last resort antibiotic, target the outer membrane of pathogens and are used to address the increasing prevalence of multidrug-resistant Gram-negative bacteria. The plasmid-encoded enzyme MCR-1 confers polymyxin resistance...