Danny Huylebroeck
Overview
Explore the profile of Danny Huylebroeck including associated specialties, affiliations and a list of published articles.
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Articles
105
Citations
3892
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Recent Articles
1.
Verploegh I, Conidi A, El Hassnaoui H, Verhoeven F, Korporaal A, Ntafoulis I, et al.
Int J Mol Sci
. 2024 Sep;
25(18).
PMID: 39337661
One of the main causes of poor prognoses in patient with glioblastoma (GBM) is drug resistance to current standard treatment, which includes chemoradiation and adjuvant temozolomide (TMZ). In addition, the...
2.
van der Ploeg E, Krabbendam L, Vroman H, van Nimwegen M, de Bruijn M, de Boer G, et al.
Nat Commun
. 2023 Aug;
14(1):5137.
PMID: 37612281
CD4 T helper 2 (Th2) cells and group 2 innate lymphoid cells are considered the main producers of type-2 cytokines that fuel chronic airway inflammation in allergic asthma. However, CD8...
3.
Bos E, Binda E, Verploegh I, Wembacher E, Hoefnagel D, Balvers R, et al.
Mol Cancer
. 2023 Aug;
22(1):129.
PMID: 37563568
Background: This Phase 1 study evaluates the intra- and peritumoral administration by convection enhanced delivery (CED) of human recombinant Bone Morphogenetic Protein 4 (hrBMP4) - an inhibitory regulator of cancer...
4.
Onrust-van Schoonhoven A, de Bruijn M, Stikker B, Brouwer R, Braunstahl G, van IJcken W, et al.
Sci Immunol
. 2023 Jul;
8(85):eadg3917.
PMID: 37418545
Memory T cells provide long-lasting defense responses through their ability to rapidly reactivate, but how they efficiently "recall" an inflammatory transcriptional program remains unclear. Here, we show that human CD4...
5.
Birkhoff J, Korporaal A, Brouwer R, Nowosad K, Milazzo C, Mouratidou L, et al.
Genes (Basel)
. 2023 Mar;
14(3).
PMID: 36980900
Functional perturbation and action mechanism studies have shown that the transcription factor Zeb2 controls cell fate decisions, differentiation, and/or maturation in multiple cell lineages in embryos and after birth. In...
6.
Dupont C, Schaffers O, Tan B, Merzouk S, Bindels E, Zwijsen A, et al.
Sci Adv
. 2023 Jan;
9(3):eadd2913.
PMID: 36652512
The murine embryonic-trophoblast-extra-embryonic endoderm (ETX) model is an integrated stem cell-based model to study early postimplantation development. It is based on the self-assembly potential of embryonic, trophoblast, and hypoblast/primitive/visceral endoderm-type...
7.
Nowosad K, Brouwer R, Odrzywolski A, Korporaal A, Gielniewski B, Wojtas B, et al.
Sci Rep
. 2022 Jul;
12(1):12835.
PMID: 35896673
The formation of the synovial joint begins with the visible emergence of a stripe of densely packed mesenchymal cells located between distal ends of the developing skeletal anlagen called the...
8.
Verploegh I, Conidi A, Brouwer R, Balcioglu H, Karras P, Makhzami S, et al.
Neuro Oncol
. 2022 May;
24(12):2133-2145.
PMID: 35639831
Background: Glioblastoma (GBM) is the most aggressive primary brain tumor. Its cellular composition is very heterogeneous, with cells exhibiting stem-cell characteristics (GSCs) that co-determine therapy resistance and tumor recurrence. Bone...
9.
Wang J, Farkas C, Benyoucef A, Carmichael C, Haigh K, Wong N, et al.
PLoS Biol
. 2021 Sep;
19(9):e3001394.
PMID: 34550965
The ZEB2 transcription factor has been demonstrated to play important roles in hematopoiesis and leukemic transformation. ZEB1 is a close family member of ZEB2 but has remained more enigmatic concerning...
10.
Boltsis I, Nowosad K, Brouwer R, Tylzanowski P, van IJcken W, Huylebroeck D, et al.
Methods Mol Biol
. 2021 Aug;
2351:165-179.
PMID: 34382189
Targeted chromatin capture (T2C) is a 3C-based method and is used to study the 3D chromatin organization, interactomes and structural changes associated with gene regulation, progression through the cell cycle,...