Danny Gauvreau
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Explore the profile of Danny Gauvreau including associated specialties, affiliations and a list of published articles.
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21
Citations
171
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Recent Articles
1.
Crowley B, Stump C, Nguyen D, Potteiger C, McWherter M, Paone D, et al.
Bioorg Med Chem Lett
. 2015 Aug;
25(21):4777-4781.
PMID: 26231160
In our efforts to develop CGRP receptor antagonists as backups to MK-3207, 2, we employed a scaffold hopping approach to identify a series of novel oxazolidinone-based compounds. The development of...
2.
Cote B, Burch J, Asante-Appiah E, Bayly C, Bedard L, Blouin M, et al.
Bioorg Med Chem Lett
. 2014 Jan;
24(3):917-22.
PMID: 24412110
The optimization of a novel series of non-nucleoside reverse transcriptase inhibitors (NNRTI) led to the identification of pyridone 36. In cell cultures, this new NNRTI shows a superior potency profile...
3.
Gauvreau D, Gupta A, Fisette A, Tom F, Cianflone K
PLoS One
. 2013 May;
8(4):e60795.
PMID: 23630572
Background: Obesity is considered as a systemic chronic low grade inflammation characterized by increased serum pro-inflammatory proteins and accumulation of macrophages within white adipose tissue (WAT) of obese patients. C5L2,...
4.
Poursharifi P, Lapointe M, Petrin D, Devost D, Gauvreau D, Hebert T, et al.
Cell Signal
. 2012 Dec;
25(4):910-8.
PMID: 23268185
Obesity is associated with inflammation characterized by increased infiltration of macrophages into adipose tissue. C5aR-like receptor 2 (C5L2) has been identified as a receptor for acylation-stimulating protein (ASP) and the...
5.
Tom F, Gauvreau D, Lapointe M, Lu H, Poursharifi P, Luo X, et al.
Eur J Cell Biol
. 2012 Dec;
92(2):61-9.
PMID: 23245988
Obesity is characterized by chronic low-grade inflammation with increased adipose tissue pro-inflammatory cytokine production. Acylation stimulating protein (ASP) stimulates triglyceride synthesis and glucose transport via its receptor C5L2. Circulating ASP...
6.
Munkonda M, Lapointe M, Miegueu P, Roy C, Gauvreau D, Richard D, et al.
PLoS One
. 2012 Oct;
7(10):e46883.
PMID: 23056509
Background: Complement 3 (C3), a key component of the innate immune system, is involved in early inflammatory responses. Acylation stimulating protein (ASP; aka C3adesArg), a C3 cleavage product, is produced...
7.
Gao Y, Cianflone K, Gauvreau D, Cui W, Ma Y
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
. 2012 Oct;
28(10):1051-4.
PMID: 23046937
Aim: To develop a 3T3-L1 pre-adipocyte model for evaluating the secretion of acylation stimulating protein (ASP) and an ELISA assay for measuring ASP production and investigate the effects and related...
8.
Gauvreau D, Roy C, Tom F, Lu H, Miegueu P, Richard D, et al.
Mol Immunol
. 2012 Mar;
51(1):73-81.
PMID: 22387270
Background: The complement system is well known for its role in innate immunity via the classical, the alternative and the lectin pathways, although recent investigations suggest expanding roles in adipose...
9.
Molinaro C, Bulger P, Lee E, Kosjek B, Lau S, Gauvreau D, et al.
J Org Chem
. 2012 Feb;
77(5):2299-309.
PMID: 22335767
In this paper, we report the development of different synthetic routes to MK-7246 (1) designed by the Process Chemistry group. The syntheses were initially designed as an enabling tool for...
10.
Roy C, Roy M, Gauvreau D, Poulin A, Tom F, Timofeeva E, et al.
Am J Physiol Endocrinol Metab
. 2011 May;
301(1):E232-41.
PMID: 21540449
Acylation-stimulating protein (ASP; also known as C3adesArg) stimulates triglyceride synthesis and glucose transport via interaction with its receptor C5L2, which is expressed peripherally (adipose tissue, muscle) and centrally. Previous studies...