Danielle M Townsley
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Explore the profile of Danielle M Townsley including associated specialties, affiliations and a list of published articles.
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49
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1516
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Recent Articles
1.
Belmontes B, Slemmons K, Su C, Liu S, Policheni A, Moriguchi J, et al.
Cancer Discov
. 2024 Sep;
15(1):139-161.
PMID: 39282709
One of the most robust synthetic lethal interactions observed in multiple functional genomic screens has been the dependency on protein arginine methyltransferase 5 (PRMT5) in cancer cells with MTAP deletion....
2.
Sparks R, Rachmaninoff N, Lau W, Hirsch D, Bansal N, Martins A, et al.
Nat Med
. 2024 Jul;
30(9):2461-2472.
PMID: 38961223
Immunological health has been challenging to characterize but could be defined as the absence of immune pathology. While shared features of some immune diseases and the concept of immunologic resilience...
3.
Maris M, Salles G, Kim W, Kim T, Lyons R, Arellano M, et al.
Target Oncol
. 2024 Apr;
19(3):321-332.
PMID: 38683495
Background: MEDI7247 is a first-in-class antibody-drug conjugate (ADC) consisting of an anti-sodium-dependent alanine-serine-cysteine transporter 2 antibody-conjugated to a pyrrolobenzodiazepine dimer. Objective: This first-in-human phase 1 trial evaluated MEDI7247 in patients...
4.
Sparks R, Rachmaninoff N, Hirsch D, Bansal N, Lau W, Martins A, et al.
Res Sq
. 2023 Mar;
PMID: 36993430
Monogenic diseases are often studied in isolation due to their rarity. Here we utilize multiomics to assess 22 monogenic immune-mediated conditions with age- and sex-matched healthy controls. Despite clearly detectable...
5.
Goldman J, Piha-Paul S, Curti B, Pedersen K, Bauer T, Groenland S, et al.
Clin Cancer Res
. 2022 Jun;
28(17):3709-3719.
PMID: 35699623
Purpose: Combination therapies targeting immunologic checkpoints have shown promise in treating multiple tumor types. We report safety and tolerability of MEDI0562, a humanized IgG1K OX40 mAb, in combination with durvalumab...
6.
Patel B, Townsley D, Scheinberg P
Semin Hematol
. 2022 May;
59(1):21-29.
PMID: 35491055
Severe aplastic anemia, a disease characterized by pancytopenia and a hypocellular marrow, is treatable by either immunosuppressive therapy (IST) or hematopoietic stem cell transplant. Much is understood about the immune-mediated...
7.
Groarke E, Patel B, Gutierrez-Rodrigues F, Rios O, Lotter J, Baldoni D, et al.
Br J Haematol
. 2021 Jan;
192(3):605-614.
PMID: 33410523
Acquired severe aplastic anaemia (SAA) has an immune pathogenesis, and immunosuppressive therapy (IST) with anti-thymocyte globulin and cyclosporine is effective therapy. Eltrombopag (EPAG) added to standard IST was associated with...
8.
Vicente A, Patel B, Gutierrez-Rodrigues F, Groarke E, Giudice V, Lotter J, et al.
Haematologica
. 2020 Dec;
105(12):2785-2794.
PMID: 33256377
Myelodysplastic syndromes (MDS) are a group of clonal myeloid disorders characterized by cytopenia and a propensity to develop acute myeloid leukemia (AML). The management of lower-risk (LR) MDS with persistent...
9.
Glisson B, Leidner R, Ferris R, Powderly J, Rizvi N, Keam B, et al.
Clin Cancer Res
. 2020 Aug;
26(20):5358-5367.
PMID: 32816951
Purpose: Immune checkpoint blockade has demonstrated clinical benefits across multiple solid tumor types; however, resistance and relapse often occur. New immunomodulatory targets, which are highly expressed in activated immune cells,...
10.
Fan X, Desmond R, Winkler T, Young D, Dumitriu B, Townsley D, et al.
Blood Adv
. 2020 Apr;
4(8):1700-1710.
PMID: 32330244
There is no standard or widely effective treatment of patients with moderate aplastic anemia (MAA) or hypo-productive uni-lineage cytopenias (UC). Eltrombopag (EPAG), a small molecule thrombopoietin mimetic, has previously been...