Danielle L Krebs
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Explore the profile of Danielle L Krebs including associated specialties, affiliations and a list of published articles.
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14
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712
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Recent Articles
1.
Matos I, Barvalia M, Chehal M, Robertson A, Kulic I, Silva J, et al.
Cancer Res Commun
. 2023 Mar;
3(3):404-419.
PMID: 36911097
Significance: Tumor-derived GCSF leads to systemic immune population changes. GCSF blockade restores immune populations, improves immunotherapy, and reduces tumor size, paralleling human colorectal cancer data. GCSF inhibition may synergize with...
2.
Lawrenson I, Krebs D, Linossi E, Zhang J, McLennan T, Collin C, et al.
Cereb Cortex
. 2015 Oct;
27(1):576-588.
PMID: 26503265
Mutations of the reelin gene cause severe defects in cerebral cortex development and profound intellectual impairment. While many aspects of the reelin signaling pathway have been identified, the molecular and...
3.
Roberts M, Bishop J, Fan X, Beer J, Kum W, Krebs D, et al.
J Immunol
. 2014 Oct;
193(10):5249-63.
PMID: 25339668
The Lyn tyrosine kinase governs the development and function of various immune cells, and its dysregulation has been linked to malignancy and autoimmunity. Using models of chemically induced colitis and...
4.
Sio A, Chehal M, Tsai K, Fan X, Roberts M, Nelson B, et al.
Cancer Res
. 2013 Aug;
73(19):5892-904.
PMID: 23913828
Cancer is associated with immune dysfunction characterized by the presence of proinflammatory and immunosuppressive cells and factors that contribute to tumor growth and progression. Here we show that mammary tumor...
5.
Krebs D, Chehal M, Sio A, Huntington N, Da M, Ziltener P, et al.
J Immunol
. 2012 Apr;
188(10):5094-105.
PMID: 22491248
The innate immune response is a first line of defense against invading pathogens; however, the magnitude of this response must be tightly regulated, as hyper- or suboptimal responses can be...
6.
Buxade M, Morrice N, Krebs D, Proud C
J Biol Chem
. 2007 Oct;
283(1):57-65.
PMID: 17965020
To identify new potential substrates for the MAP kinase signal-integrating kinases (Mnks), we employed a proteomic approach. The Mnks are targeted to the translational machinery through their interaction with the...
7.
Greig K, Antonchuk J, Metcalf D, Morgan P, Krebs D, Zhang J, et al.
Mol Cell Biol
. 2007 Jun;
27(16):5849-59.
PMID: 17548465
Carbohydrate modification of proteins includes N-linked and O-linked glycosylation, proteoglycan formation, glycosylphosphatidylinositol anchor synthesis, and O-GlcNAc modification. Each of these modifications requires the sugar nucleotide UDP-GlcNAc, which is produced via...
8.
Majewski I, Metcalf D, Mielke L, Krebs D, Ellis S, Carpinelli M, et al.
Proc Natl Acad Sci U S A
. 2006 Sep;
103(38):14146-51.
PMID: 16966598
We have generated mice from a N-ethyl-N-nitrosourea mutagenesis screen that carry a mutation in the translation initiation codon of Gata-1, termed Plt13, which is equivalent to mutations found in patients...
9.
Voss A, Krebs D, Thomas T
EMBO J
. 2006 Jul;
25(15):3652-63.
PMID: 16858399
The mechanisms regulating the size of the cerebral cortex are poorly understood. Here, we demonstrate that the Rap1 guanine nucleotide exchange factor, C3G (Grf2, Rapgef1), controls the size of the...
10.
Wormald S, Zhang J, Krebs D, Mielke L, Silver J, Alexander W, et al.
J Biol Chem
. 2006 Feb;
281(16):11135-43.
PMID: 16473883
Negative feedback is a mechanism commonly employed in biological processes as a means of maintaining homeostasis. We have investigated the roles of suppressor of cytokine signaling (SOCS) proteins in regulating...