Tumor-derived GCSF Alters Tumor and Systemic Immune System Cell Subset Composition and Signaling

Overview

Journal Cancer Res Commun

Specialty Oncology

Date 2023 Mar 13

PMID 36911097

Authors

Israel Matos

Maunish Barvalia

Manreet K Chehal

A Gordon Robertson

Iva Kulic

Jessica A F D Silva

Abhinandan Ranganathan

Amy Short

Yu-Hsuan Huang

Erin Long

John J Priatel

Salim Dhanji

Brad H Nelson

Danielle L Krebs

Kenneth W Harder

Affiliations

Soon will be listed here.

Abstract

Significance: Tumor-derived GCSF leads to systemic immune population changes. GCSF blockade restores immune populations, improves immunotherapy, and reduces tumor size, paralleling human colorectal cancer data. GCSF inhibition may synergize with current immunotherapies to treat GCSF-secreting tumors.

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