Daniele Bolognini
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Explore the profile of Daniele Bolognini including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Barki N, Jenkins L, Marsango S, Dedeo D, Bolognini D, Dwomoh L, et al.
Elife
. 2023 Dec;
12.
PMID: 38085667
Free fatty acid receptor 2 (FFAR2) is activated by short-chain fatty acids and expressed widely, including in white adipocytes and various immune and enteroendocrine cells. Using both wild-type human FFAR2...
2.
Barki N, Bolognini D, Borjesson U, Jenkins L, Riddell J, Hughes D, et al.
Elife
. 2022 Mar;
11.
PMID: 35229717
Volatile small molecules, including the short-chain fatty acids (SCFAs), acetate and propionate, released by the gut microbiota from the catabolism of nondigestible starches, can act in a hormone-like fashion via...
3.
Bolognini D, Dedeo D, Milligan G
Curr Opin Endocr Metab Res
. 2020 Aug;
16:1-9.
PMID: 32835130
FFA2 and FFA3 are receptors for short-chain fatty acids which are produced in prodigious amounts by fermentation of poorly digested carbohydrates by gut bacteria. Understanding the roles of these receptors...
4.
Bolognini D, Barki N, Butcher A, Hudson B, Sergeev E, Molloy C, et al.
Nat Chem Biol
. 2019 Apr;
15(5):489-498.
PMID: 30992568
Differentiating actions of short chain fatty acids (SCFAs) at free fatty acid receptor 2 (FFA2) from other free fatty acid-responsive receptors and from non-receptor-mediated effects has been challenging. Using a...
5.
Mancini S, Al Mahmud Z, Jenkins L, Bolognini D, Newman R, Barnes M, et al.
Sci Rep
. 2019 Feb;
9(1):1861.
PMID: 30755705
Many members of the G protein-coupled receptor family, including examples with clear therapeutic potential, remain poorly characterised. This often reflects limited availability of suitable tool ligands with which to interrogate...
6.
Svolos V, Hansen R, Nichols B, Quince C, Ijaz U, Papadopoulou R, et al.
Gastroenterology
. 2018 Dec;
156(5):1354-1367.e6.
PMID: 30550821
Background & Aims: Exclusive enteral nutrition (EEN) is the only established dietary treatment for Crohn's disease (CD), but its acceptability is limited. There is a need for novel dietary treatments...
7.
Hansen A, Sergeev E, Bolognini D, Sprenger R, Ekberg J, Ejsing C, et al.
J Med Chem
. 2018 Sep;
61(21):9534-9550.
PMID: 30247908
Free fatty acid receptor 2 (FFA2/GPR43) is a receptor for short-chain fatty acids reported to be involved in regulation of metabolism, appetite, fat accumulation, and inflammatory responses and is a...
8.
Sergeev E, Hansen A, Bolognini D, Kawakami K, Kishi T, Aoki J, et al.
Sci Rep
. 2017 Oct;
7(1):13741.
PMID: 29061999
Free Fatty Acid Receptor 2 is a GPCR activated by short chain fatty acids produced in high levels in the lower gut by microbial fermentation of non-digestible carbohydrates. A major...
9.
Milligan G, Bolognini D, Sergeev E
Handb Exp Pharmacol
. 2016 Oct;
236:17-32.
PMID: 27757758
A large number of reviews and commentaries have highlighted the potential role of the short-chain fatty acid receptors GPR41 (FFA3) and, particularly, GPR43 (FFA2) as an interface between the intestinal...
10.
Bolognini D, Moss C, Nilsson K, Petersson A, Donnelly I, Sergeev E, et al.
J Biol Chem
. 2016 Jul;
291(36):18915-31.
PMID: 27385588
The short chain fatty acid receptor FFA2 is able to stimulate signaling via both Gi- and Gq/G11-promoted pathways. These pathways are believed to control distinct physiological end points but FFA2...