Daniel T Harris
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Explore the profile of Daniel T Harris including associated specialties, affiliations and a list of published articles.
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10
Citations
394
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Recent Articles
1.
Singh N, Alonso J, Harris D, Anderson S, Ma J, Hellman L, et al.
Biochemistry
. 2020 Oct;
59(43):4163-4175.
PMID: 33074657
T cell receptors (TCRs) orchestrate cellular immunity by recognizing peptides presented by a range of major histocompatibility complex (MHC) proteins. Naturally occurring TCRs bind the composite peptide/MHC surface, recognizing peptides...
2.
Sharma P, Harris D, Stone J, Kranz D
Cancer Immunol Res
. 2019 Sep;
7(12):2025-2035.
PMID: 31548259
Despite progress in adoptive T-cell therapies, the identification of targets remains a challenge. Although chimeric antigen receptors recognize cell-surface antigens, T-cell receptors (TCR) have the advantage that they can target...
3.
Harris D, Hager M, Smith S, Cai Q, Stone J, Kruger P, et al.
J Immunol
. 2017 Dec;
200(3):1088-1100.
PMID: 29288199
Adoptive T cell therapies have achieved significant clinical responses, especially in hematopoietic cancers. Two types of receptor systems have been used to redirect the activity of T cells, normal heterodimeric...
4.
Harris D, Wang N, Riley T, Anderson S, Singh N, Procko E, et al.
J Biol Chem
. 2016 Sep;
291(47):24566-24578.
PMID: 27681597
Proteins are often engineered to have higher affinity for their ligands to achieve therapeutic benefit. For example, many studies have used phage or yeast display libraries of mutants within complementarity-determining...
5.
Harris D, Singh N, Cai Q, Smith S, Vander Kooi C, Procko E, et al.
Structure
. 2016 May;
24(7):1142-1154.
PMID: 27238970
Utilizing a diverse binding site, T cell receptors (TCRs) specifically recognize a composite ligand comprised of a foreign peptide and a major histocompatibility complex protein (MHC). To help understand the...
6.
Harris D, Kranz D
Trends Pharmacol Sci
. 2015 Dec;
37(3):220-230.
PMID: 26705086
The tumor-killing properties of T cells provide tremendous opportunities to treat cancer. Adoptive T cell therapies have begun to harness this potential by endowing a functionally diverse repertoire of T...
7.
Smith S, Harris D, Kranz D
Methods Mol Biol
. 2015 Jun;
1319:95-141.
PMID: 26060072
The αβ heterodimeric T cell receptor (TCR) recognizes peptide antigens that are transported to the cell surface as a complex with a protein encoded by the major histocompatibility complex (MHC)....
8.
Stone J, Harris D, Kranz D
Curr Opin Immunol
. 2015 Jan;
33:16-22.
PMID: 25618219
Recent studies have shown that the range of affinities of T cell receptors (TCRs) against non-mutated cancer peptide/class I complexes are lower than TCR affinities for foreign antigens. Raising the...
9.
Stone J, Harris D, Soto C, Chervin A, Aggen D, Roy E, et al.
Cancer Immunol Immunother
. 2014 Aug;
63(11):1163-76.
PMID: 25082071
Adoptive transfer of genetically modified T cells to treat cancer has shown promise in several clinical trials. Two main strategies have been applied to redirect T cells against cancer: (1)...
10.
Martin S, Harris D, Shisler J
J Virol
. 2012 Jun;
86(18):9629-39.
PMID: 22740414
MVA is an attenuated strain of vaccinia virus (VACV) that is a popular vaccine vector. MVA infection activates NF-κB. For 293T cells, it is known that MVA early gene expression...