Daniel T Gewirth
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Explore the profile of Daniel T Gewirth including associated specialties, affiliations and a list of published articles.
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35
Citations
1261
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Recent Articles
1.
Que N, Seidler P, Aw W, Chiosis G, Gewirth D
Proteins
. 2024 Oct;
93(3):654-672.
PMID: 39473058
Grp94 is the endoplasmic reticulum paralog of the hsp90 family of chaperones, which have been targeted for therapeutic intervention via their highly conserved ATP binding sites. The design of paralog-selective...
2.
Amankwah Y, Fleifil Y, Unruh E, Collins P, Wang Y, Vitou K, et al.
Proc Natl Acad Sci U S A
. 2024 Mar;
121(12):e2309326121.
PMID: 38483986
Hsp90s are ATP-dependent chaperones that collaborate with co-chaperones and Hsp70s to remodel client proteins. Grp94 is the ER Hsp90 homolog essential for folding multiple secretory and membrane proteins. Grp94 interacts...
3.
Buchner J, Alasady M, Backe S, Blagg B, Carpenter R, Colombo G, et al.
Cell Stress Chaperones
. 2024 Feb;
29(1):88-96.
PMID: 38316354
No abstract available.
4.
Que N, Seidler P, Aw W, Chiosis G, Gewirth D
bioRxiv
. 2023 Aug;
PMID: 37577523
Grp94 is the endoplasmic reticulum paralog of the hsp90 family of chaperones, which have been targeted for therapeutic intervention via their highly conserved ATP binding sites. The design of paralog-selective...
5.
Li A, Chang Y, Song N, Wu X, Chung D, Riesenberg B, et al.
J Immunother Cancer
. 2022 Sep;
10(9).
PMID: 36096533
Background: Immune checkpoint blockade (ICB) has revolutionized cancer immunotherapy. However, most patients with cancer fail to respond clinically. One potential reason is the accumulation of immunosuppressive transforming growth factor β...
6.
Yan P, Patel H, Sharma S, Corben A, Wang T, Panchal P, et al.
Cell Rep
. 2020 Jul;
31(13):107840.
PMID: 32610141
Stresses associated with disease may pathologically remodel the proteome by both increasing interaction strength and altering interaction partners, resulting in proteome-wide connectivity dysfunctions. Chaperones play an important role in these...
7.
Metelli A, Wu B, Riesenberg B, Guglietta S, Huck J, Mills C, et al.
Sci Transl Med
. 2020 Jan;
12(525).
PMID: 31915300
Cancer-associated thrombocytosis and high concentrations of circulating transforming growth factor-β1 (TGF-β1) are frequently observed in patients with progressive cancers. Using genetic and pharmacological approaches, we show a direct link between...
8.
Huck J, Que N, Immormino R, Shrestha L, Taldone T, Chiosis G, et al.
J Biol Chem
. 2019 Sep;
294(44):16010-16019.
PMID: 31501246
The hsp90 chaperones govern the function of essential client proteins critical for normal cell function as well as cancer initiation and progression. Hsp90 activity is driven by ATP, which binds...
9.
Huck J, Que N, Sharma S, Taldone T, Chiosis G, Gewirth D
Proteins
. 2019 May;
87(10):869-877.
PMID: 31141217
Hsp90α and Hsp90β are implicated in a number of cancers and neurodegenerative disorders but the lack of selective pharmacological probes confounds efforts to identify their individual roles. Here, we analyzed...
10.
Fiandalo M, Gewirth D, Mohler J
Asian J Urol
. 2019 Feb;
6(1):50-56.
PMID: 30775248
Prostate cancer (PCa) growth and progression rely on the interaction between the androgen receptor (AR) and the testicular ligands, testosterone and dihydrotestosterone (DHT). Almost all men with advanced PCa receive...