Daniel S Widmer
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Explore the profile of Daniel S Widmer including associated specialties, affiliations and a list of published articles.
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18
Citations
697
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Recent Articles
1.
Vergara I, Mintoff C, Sandhu S, Mcintosh L, Young R, Wong S, et al.
Nat Commun
. 2021 Mar;
12(1):1434.
PMID: 33664264
Although melanoma is initiated by acquisition of point mutations and limited focal copy number alterations in melanocytes-of-origin, the nature of genetic changes that characterise lethal metastatic disease is poorly understood....
2.
Raaijmakers M, Widmer D, Narechania A, Eichhoff O, Freiberger S, Wenzina J, et al.
Oncotarget
. 2016 Oct;
7(47):77163-77174.
PMID: 27791198
Acquired chemotherapeutic resistance of cancer cells can result from a Darwinistic evolution process in which heterogeneity plays an important role. In order to understand the impact of genetic heterogeneity on...
3.
Rozati S, Cheng P, Widmer D, Fujii K, Levesque M, Dummer R
Clin Cancer Res
. 2015 Dec;
22(8):2020-31.
PMID: 26660520
Purpose: Cutaneous T-cell lymphomas (CTCL) are a heterogeneous group of malignancies that despite available therapies commonly relapse. The emergence of combination epigenetic therapies in other hematologic malignancies have made investigation...
4.
Widmer D, Eichhoff O, Dummer R, Levesque M
Exp Dermatol
. 2015 May;
24(9):659-60.
PMID: 25977109
No abstract available.
5.
Cheng P, Shakhova O, Widmer D, Eichhoff O, Zingg D, Frommel S, et al.
Genome Biol
. 2015 Apr;
16:42.
PMID: 25885555
Background: Melanoma is the most fatal skin cancer displaying a high degree of molecular heterogeneity. Phenotype switching is a mechanism that contributes to melanoma heterogeneity by altering transcription profiles for...
6.
Raaijmakers M, Widmer D, Maudrich M, Koch T, Langer A, Flace A, et al.
Exp Dermatol
. 2015 Mar;
24(5):377-80.
PMID: 25739758
Fibroblast contamination can make establishing primary melanoma cell cultures from native biopsies a major challenge, due to fibroblasts overgrowing the melanoma cells. Standard protocols therefore enrich for highly proliferative melanoma...
7.
Schlegel N, von Planta A, Widmer D, Dummer R, Christofori G
Exp Dermatol
. 2014 Nov;
24(1):22-8.
PMID: 25363503
Epithelial to mesenchymal transition (EMT) is a programme defined in epithelial cells and recognized as playing a critical role in cancer progression. Although melanoma is not a cancer of epithelial...
8.
Bottcher-Haberzeth S, Biedermann T, Klar A, Widmer D, Neuhaus K, Schiestl C, et al.
Exp Dermatol
. 2014 Oct;
24(1):16-21.
PMID: 25346346
In our laboratory, we have been using human pigmented dermo-epidermal skin substitutes for short-term experiments since several years. Little is known, however, about the long-term biology of such constructs after...
9.
Biedermann T, Bottcher-Haberzeth S, Klar A, Widmer D, Pontiggia L, Weber A, et al.
Tissue Eng Part A
. 2014 Oct;
21(5-6):960-9.
PMID: 25300246
It has been shown in vitro that melanocyte proliferation and function in palmoplantar skin is regulated by mesenchymal factors derived from fibroblasts. In this study, we investigated in vivo the...
10.
Lenggenhager D, Curioni-Fontecedro A, Storz M, Shakhova O, Sommer L, Widmer D, et al.
Transl Oncol
. 2014 Apr;
7(2):206-12.
PMID: 24746711
Despite existing vaccination strategies targeting TRP-2, its function is not yet fully understood. TRP-2 is an enzyme involved in melanin biosynthesis and therefore discussed as a differentiation antigen. However, in...