Daniel S Day
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Explore the profile of Daniel S Day including associated specialties, affiliations and a list of published articles.
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16
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3382
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Recent Articles
1.
Hsu A, Duan Q, Day D, Luo X, McMahon S, Huang Y, et al.
Nat Commun
. 2022 Jul;
13(1):4345.
PMID: 35896549
Heart failure with reduced ejection fraction (HFrEF) is associated with high mortality, highlighting an urgent need for new therapeutic strategies. As stress-activated cardiac signaling cascades converge on the nucleus to...
2.
Wang C, Xu Q, Zhang X, Day D, Abraham B, Lun K, et al.
Cell Mol Life Sci
. 2022 Jun;
79(6):338.
PMID: 35665862
The bromodomain and extraterminal motif (BET) proteins are critical drug targets for diseases. The precise functions and relationship of BRD2 with other BET proteins remain elusive mechanistically. Here, we used...
3.
Debruyne D, Dries R, Sengupta S, Seruggia D, Gao Y, Sharma B, et al.
Nature
. 2019 Aug;
572(7771):676-680.
PMID: 31391581
The CCCTC-binding factor (CTCF), which anchors DNA loops that organize the genome into structural domains, has a central role in gene control by facilitating or constraining interactions between genes and...
4.
Krajewska M, Dries R, Grassetti A, Dust S, Gao Y, Huang H, et al.
Nat Commun
. 2019 Apr;
10(1):1757.
PMID: 30988284
Cyclin-dependent kinase 12 (CDK12) modulates transcription elongation by phosphorylating the carboxy-terminal domain of RNA polymerase II and selectively affects the expression of genes involved in the DNA damage response (DDR)...
5.
Wang S, Chen J, Garcia S, Liang X, Zhang F, Yan P, et al.
Genome Res
. 2019 Jan;
29(2):193-207.
PMID: 30670628
Cell behaviors are dictated by epigenetic and transcriptional programs. Little is known about how extracellular stimuli modulate these programs to reshape gene expression and control cell behavioral responses. Here, we...
6.
Sabari B, DallAgnese A, Boija A, Klein I, Coffey E, Shrinivas K, et al.
Science
. 2018 Jun;
361(6400).
PMID: 29930091
Super-enhancers (SEs) are clusters of enhancers that cooperatively assemble a high density of the transcriptional apparatus to drive robust expression of genes with prominent roles in cell identity. Here we...
7.
Weintraub A, Li C, Zamudio A, Sigova A, Hannett N, Day D, et al.
Cell
. 2017 Dec;
171(7):1573-1588.e28.
PMID: 29224777
There is considerable evidence that chromosome structure plays important roles in gene control, but we have limited understanding of the proteins that contribute to structural interactions between gene promoters and...
8.
Chen J, Fu Y, Day D, Sun Y, Wang S, Liang X, et al.
Nat Commun
. 2017 Aug;
8(1):383.
PMID: 28851877
Release of promoter-proximally paused RNA polymerase II (RNAPII) is a recently recognized transcriptional regulatory checkpoint. The biological roles of RNAPII pause release and the mechanisms by which extracellular signals control...
9.
Hnisz D, Day D, Young R
Cell
. 2016 Nov;
167(5):1188-1200.
PMID: 27863240
Understanding how transcriptional enhancers control over 20,000 protein-coding genes to maintain cell-type-specific gene expression programs in all human cells is a fundamental challenge in regulatory biology. Recent studies suggest that...
10.
Day D, Zhang B, Stevens S, Ferrari F, Larschan E, Park P, et al.
Genome Biol
. 2016 Jun;
17(1):120.
PMID: 27259512
Background: For many genes, RNA polymerase II stably pauses before transitioning to productive elongation. Although polymerase II pausing has been shown to be a mechanism for regulating transcriptional activation, the...