Daniel Margerie
Overview
Explore the profile of Daniel Margerie including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
275
Followers
0
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Recent Articles
1.
Biesemann N, Margerie D, Asbrand C, Rehberg M, Savova V, Agueusop I, et al.
Sci Transl Med
. 2023 Feb;
15(681):eabq4419.
PMID: 36724239
Rheumatoid arthritis (RA) is one of the most common autoimmune diseases affecting primarily the joints. Despite successful therapies including antibodies against tumor necrosis factor (TNF) and interleukin-6 (IL-6) receptor, only...
2.
Ziegler N, Bader E, Epanchintsev A, Margerie D, Kannt A, Schmoll D
J Biol Chem
. 2021 Jan;
295(51):17659-17671.
PMID: 33454005
AMP-activated protein kinase (AMPK) is a key regulator of energy metabolism that phosphorylates a wide range of proteins to maintain cellular homeostasis. AMPK consists of three subunits: α, β, and...
3.
Ziegler N, Raichur S, Brunner B, Hemmann U, Stolte M, Schwahn U, et al.
Front Endocrinol (Lausanne)
. 2020 Sep;
11:598.
PMID: 32982982
Histone deacetylases (HDACs) are important regulators of epigenetic gene modification that are involved in the transcriptional control of metabolism. In particular class IIa HDACs have been shown to affect hepatic...
4.
Margerie D, Lefebvre P, Raverdy V, Schwahn U, Ruetten H, Larsen P, et al.
BMC Med Genomics
. 2019 Jun;
12(1):80.
PMID: 31159817
Background: Clinical data identified an association between the use of HMG-CoA reductase inhibitors (statins) and incident diabetes in patients with underlying diabetes risk factors such as obesity, hypertension and dyslipidemia....
5.
Brachs S, Polack J, Brachs M, Jahn-Hofmann K, Elvert R, Pfenninger A, et al.
Diabetes
. 2018 Dec;
68(3):527-542.
PMID: 30552109
Antisense oligonucleotide knockdown (ASO-KD) of nicotinamide -methyltransferase (NNMT) in high-fat diet (HFD)-fed mice has been reported to reduce weight gain and plasma insulin levels and to improve glucose tolerance. Using...
6.
Solimena M, Schulte A, Marselli L, Ehehalt F, Richter D, Kleeberg M, et al.
Diabetologia
. 2017 Nov;
61(3):641-657.
PMID: 29185012
Aims/hypothesis: Pancreatic islet beta cell failure causes type 2 diabetes in humans. To identify transcriptomic changes in type 2 diabetic islets, the Innovative Medicines Initiative for Diabetes: Improving beta-cell function...
7.
Brachs S, Winkel A, Polack J, Tang H, Brachs M, Margerie D, et al.
PLoS One
. 2017 Feb;
12(2):e0172657.
PMID: 28207865
[This corrects the article DOI: 10.1371/journal.pone.0166110.].
8.
Brachs S, Winkel A, Tang H, Birkenfeld A, Brunner B, Jahn-Hofmann K, et al.
Mol Metab
. 2016 Nov;
5(11):1072-1082.
PMID: 27818933
Objective: Non-alcoholic fatty liver disease is a world-wide health concern and risk factor for cardio-metabolic diseases. Citrate uptake modifies intracellular hepatic energy metabolism and is controlled by the conserved sodium-dicarboxylate...
9.
Brachs S, Winkel A, Polack J, Tang H, Brachs M, Margerie D, et al.
PLoS One
. 2016 Nov;
11(11):e0166110.
PMID: 27814396
The transcription factor NF-E2-related factor 2 (Nrf2) induces cytoprotective genes, but has also been linked to the regulation of hepatic energy metabolism. In order to assess the pharmacological potential of...
10.
Winkel A, Engel C, Margerie D, Kannt A, Szillat H, Glombik H, et al.
J Biol Chem
. 2015 Oct;
290(47):28446-28455.
PMID: 26459563
The activation of the transcription factor NF-E2-related factor 2 (Nrf2) maintains cellular homeostasis in response to oxidative stress by the regulation of multiple cytoprotective genes. Without stressors, the activity of...