Sebastian Brachs
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Explore the profile of Sebastian Brachs including associated specialties, affiliations and a list of published articles.
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Articles
36
Citations
491
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Recent Articles
1.
Brachs S, Soll D, Beer F, Huckauf N, Konkar A, Spranger J, et al.
Eur J Endocrinol
. 2025 Feb;
192(2):91-99.
PMID: 39935317
Objective: Given the promising effects of GLP-1/GIP/glucagon receptor triagonists on weight loss in animals and humans, improved understanding of underlying mechanism is required. We investigated a direct lipolytic effect of...
2.
Konar E, Brachs S, Mai K, Waghmare S, Policar T, Samarin A, et al.
J Anim Sci
. 2025 Jan;
103.
PMID: 39761344
Ovulation, fertilization, and embryo development are orchestrated and synchronized processes essential for the optimal health of offspring. Postovulatory aging disrupts this synchronization and impairs oocyte quality. In addition, oocyte aging...
3.
Sun R, Gaerz M, Oeing C, Mai K, Brachs S
Front Neurosci
. 2024 Oct;
18:1456307.
PMID: 39371613
Introduction: Holistic phenotyping of rodent models is increasing, with a growing awareness of the 3Rs and the fact that specialized experimental setups can also impose artificial restrictions. Activity is an...
4.
Konar E, Mai K, Brachs S, Waghmare S, Samarin A, Policar T, et al.
Front Vet Sci
. 2024 Jul;
11:1389070.
PMID: 38952806
Introduction: Post-ovulatory aging is a time-dependent deterioration of ovulated oocytes and a major limiting factor reducing the fitness of offspring. This process may lead to the activation of cell death...
5.
Kopp J, Koch L, Lyubenova H, Kuchler O, Holtgrewe M, Ivanov A, et al.
Hum Genet
. 2024 Apr;
143(5):683-694.
PMID: 38592547
Generalized lipodystrophy is a feature of various hereditary disorders, often leading to a progeroid appearance. In the present study we identified a missense and a frameshift variant in a compound...
6.
Sandforth L, Brachs S, Reinke J, Willmes D, Sancar G, Seigner J, et al.
Mol Metab
. 2024 Mar;
82:101905.
PMID: 38431218
Objective: Kallistatin (KST), also known as SERPIN A4, is a circulating, broadly acting human plasma protein with pleiotropic properties. Clinical studies in humans revealed reduced KST levels in obesity. The...
7.
Zeidler J, Chini C, Kanamori K, Kashyap S, Espindola-Netto J, Thompson K, et al.
iScience
. 2022 Nov;
25(11):105431.
PMID: 36388973
In mammals, nicotinamide (NAM) is the primary NAD precursor available in circulation, a signaling molecule, and a precursor for methyl-nicotinamide (M-NAM) synthesis. However, our knowledge about how the body regulates...
8.
Cosovanu C, Resch P, Jordan S, Lehmann A, Ralser M, Farztdinov V, et al.
J Exp Med
. 2022 Sep;
219(12).
PMID: 36121416
The primary function of the small intestine (SI) is to absorb nutrients to maintain whole-body energy homeostasis. Enterocytes are the major epithelial cell type facilitating nutrient sensing and uptake. However,...
9.
Mackert O, Wirth E, Sun R, Winkler J, Liu A, Renko K, et al.
Mol Metab
. 2022 Aug;
64:101563.
PMID: 35944898
Objective: Alterations in mitochondrial function play an important role in the development of various diseases, such as obesity, insulin resistance, steatohepatitis, atherosclerosis and cancer. However, accurate assessment of mitochondrial respiration...
10.
Lohr D, Thiele A, Stahnke M, Braun V, Smeir E, Spranger J, et al.
Front Cardiovasc Med
. 2022 Apr;
9:839714.
PMID: 35449873
Background: Obesity exerts multiple deleterious effects on the heart that may ultimately lead to cardiac failure. This study sought to characterize myocardial microstructure and function in an experimental model of...