Daniel Mar
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Explore the profile of Daniel Mar including associated specialties, affiliations and a list of published articles.
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20
Citations
329
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Recent Articles
11.
Kanter J, Shao B, Kramer F, Barnhart S, Shimizu-Albergine M, Vaisar T, et al.
J Clin Invest
. 2019 Jul;
129(10):4165-4179.
PMID: 31295146
Type 1 diabetes mellitus (T1DM) increases the risk of atherosclerotic cardiovascular disease (CVD) in humans by poorly understood mechanisms. Using mouse models of T1DM-accelerated atherosclerosis, we found that relative insulin...
12.
Bomsztyk K, Mar D, Wang Y, Denisenko O, Ware C, Frazar C, et al.
Nucleic Acids Res
. 2019 Mar;
47(12):e69.
PMID: 30927002
Chromatin immunoprecipitation (ChIP) is the most widely used approach for identification of genome-associated proteins and their modifications. We have previously introduced a microplate-based ChIP platform, Matrix ChIP, where the entire...
13.
Denisenko O, Mar D, Trawczynski M, Bomsztyk K
Aging (Albany NY)
. 2018 May;
10(5):1133-1145.
PMID: 29846172
Dysregulation of gene expression is a hallmark of aging. We examined epigenetic mechanisms that mediate aberrant expression of laminin genes in aging rat kidneys. In old animals, no alterations were...
14.
Denisenko O, Lucas E, Sun C, Watkins A, Mar D, Bomsztyk K, et al.
Biochim Biophys Acta
. 2016 Apr;
1859(7):906-13.
PMID: 27060415
Cells and organisms respond to nutrient deprivation by decreasing global rates of transcription, translation and DNA replication. To what extent such changes can be reversed is largely unknown. We examined...
15.
Gharib S, Mar D, Bomsztyk K, Denisenko O, Dhanireddy S, Liles W, et al.
Shock
. 2015 Nov;
45(2):148-56.
PMID: 26536201
Sepsis-induced multiple organ dysfunction syndrome (MODS) is a major cause of morbidity and mortality in critically ill patients and remains impervious to most therapeutic interventions. We utilized a clinically relevant...
16.
Mar D, Gharib S, Zager R, Johnson A, Denisenko O, Bomsztyk K
Kidney Int
. 2015 Jun;
88(4):734-44.
PMID: 26061546
Aberrant gene expression is a molecular hallmark of acute kidney injury (AKI). As epigenetic processes control gene expression in a cell- and environment-defined manner, understanding the epigenetic pathways that regulate...
17.
Bomsztyk K, Mar D, An D, Sharifian R, Mikula M, Gharib S, et al.
Crit Care
. 2015 May;
19:225.
PMID: 25959381
Introduction: The Tie2/angiopoietin (Tie2/Ang) and vascular endothelial growth factor receptor-ligand systems (VEGFR/VEGF) are recognized to play important roles in the regulation of microvascular endothelial function. Downregulation of these genes during...
18.
Reddy M, Sumanth P, Lanting L, Yuan H, Wang M, Mar D, et al.
Kidney Int
. 2013 Oct;
85(2):362-73.
PMID: 24088954
Epigenetic mechanisms such as chromatin histone H3 lysine methylation and acetylation have been implicated in diabetic vascular complications. However, histone modification profiles at pathologic genes associated with diabetic nephropathy in...
19.
Bomsztyk K, Flanagin S, Mar D, Mikula M, Johnson A, Zager R, et al.
PLoS One
. 2013 Aug;
8(7):e70322.
PMID: 23936185
Background: As a consequence of acute kidney injury (AKI), proximal tubular cells hyperrespond to endotoxin (lipopolysaccharide, LPS) by exaggerated renal Tnf-α Production. This LPS hyperresponsiveness is transcriptionally mediated. The epigenetic...
20.
Komers R, Mar D, Denisenko O, Xu B, Oyama T, Bomsztyk K
Lab Invest
. 2013 Mar;
93(5):543-52.
PMID: 23508046
Epigenetic processes are increasingly being recognized as factors in the pathophysiology of diabetes complications, but few chromatin studies have been done in diabetic nephropathy (DN). We hypothesized that changes in...