Daniel M Konecki
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Explore the profile of Daniel M Konecki including associated specialties, affiliations and a list of published articles.
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8
Citations
63
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Recent Articles
1.
Konecki D, Hamrick S, Wang C, Agosto M, Wensel T, Lichtarge O
J Biol Chem
. 2023 Jun;
299(7):104896.
PMID: 37290531
Measuring the relative effect that any two sequence positions have on each other may improve protein design or help better interpret coding variants. Current approaches use statistics and machine learning...
2.
Hsu T, Asmussen J, Koire A, Choi B, Gadhikar M, Huh E, et al.
Genome Res
. 2022 Mar;
32(5):916-929.
PMID: 35301263
Genetic variants drive the evolution of traits and diseases. We previously modeled these variants as small displacements in fitness landscapes and estimated their functional impact by differentiating the evolutionary relationship...
3.
Wang C, Konecki D, Marciano D, Govindarajan H, Williams A, Wastuwidyaningtyas B, et al.
Bioinformatics
. 2021 May;
37(22):4033-4040.
PMID: 34043002
Motivation: Since the first recognized case of COVID-19, more than 100 million people have been infected worldwide. Global efforts in drug and vaccine development to fight the disease have yielded...
4.
Kim Y, Al-Ramahi I, Koire A, Wilson S, Konecki D, Mota S, et al.
Alzheimers Dement
. 2021 Feb;
17(5):831-846.
PMID: 33576571
The strongest genetic risk factor for idiopathic late-onset Alzheimer's disease (LOAD) is apolipoprotein E (APOE) ɛ4, while the APOE ɛ2 allele is protective. However, there are paradoxical APOE ɛ4 carriers...
5.
Wang C, Konecki D, Marciano D, Govindarajan H, Williams A, Wastuwidyaningtyas B, et al.
Res Sq
. 2020 Oct;
PMID: 33106800
Since the first recognized case of COVID-19, more than 100 million people have been infected worldwide. Global efforts in drug and vaccine development to fight the disease have yielded vaccines...
6.
Lin C, Konecki D, Liu M, Wilson S, Nassar H, Wilkins A, et al.
Bioinformatics
. 2018 Oct;
35(9):1536-1543.
PMID: 30304494
Motivation: Precision medicine is an emerging field with hopes to improve patient treatment and reduce morbidity and mortality. To these ends, computational approaches have predicted associations among genes, chemicals and...
7.
Lua R, Wilson S, Konecki D, Wilkins A, Venner E, Morgan D, et al.
Nucleic Acids Res
. 2015 Nov;
44(D1):D308-12.
PMID: 26590254
The structure and function of proteins underlie most aspects of biology and their mutational perturbations often cause disease. To identify the molecular determinants of function as well as targets for...
8.
Amarnath S, Flomerfelt F, Costanzo C, Foley J, Mariotti J, Konecki D, et al.
Autophagy
. 2010 Apr;
6(4):523-41.
PMID: 20404486
Murine T cells exposed to rapamycin maintain flexibility towards Th1/Tc1 differentiation, thereby indicating that rapamycin promotion of regulatory T cells (Tregs) is conditional. The degree to which rapamycin might inhibit...