Chih-Hsu Lin
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Explore the profile of Chih-Hsu Lin including associated specialties, affiliations and a list of published articles.
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12
Citations
54
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Recent Articles
1.
Tiong K, Sintupisut N, Lin M, Cheng C, Woolston A, Lin C, et al.
PLOS Digit Health
. 2023 Feb;
1(12):e0000151.
PMID: 36812605
Cancer cells harbor molecular alterations at all levels of information processing. Genomic/epigenomic and transcriptomic alterations are inter-related between genes, within and across cancer types and may affect clinical phenotypes. Despite...
2.
Hsu T, Asmussen J, Koire A, Choi B, Gadhikar M, Huh E, et al.
Genome Res
. 2022 Mar;
32(5):916-929.
PMID: 35301263
Genetic variants drive the evolution of traits and diseases. We previously modeled these variants as small displacements in fitness landscapes and estimated their functional impact by differentiating the evolutionary relationship...
3.
Lin C, Lichtarge O
Bioinformatics
. 2021 May;
37(17):2675-2681.
PMID: 34042953
Motivation: Cancer dependencies provide potential drug targets. Unfortunately, dependencies differ among cancers and even individuals. To this end, visible neural networks (VNNs) are promising due to robust performance and the...
4.
Pham M, Wilson S, Govindarajan H, Lin C, Lichtarge O
Bioinformatics
. 2020 Apr;
36(11):3623.
PMID: 32259836
No abstract available.
5.
Pham M, Wilson S, Govindarajan H, Lin C, Lichtarge O
Bioinformatics
. 2019 Nov;
36(6):1881-1888.
PMID: 31738408
Motivation: In light of the massive growth of the scientific literature, text mining is increasingly used to extract biological pathways. Though multiple tools explore individual connections between genes, diseases and...
6.
Lin C, Konecki D, Liu M, Wilson S, Nassar H, Wilkins A, et al.
Bioinformatics
. 2018 Oct;
35(9):1536-1543.
PMID: 30304494
Motivation: Precision medicine is an emerging field with hopes to improve patient treatment and reduce morbidity and mortality. To these ends, computational approaches have predicted associations among genes, chemicals and...
7.
Chen Y, Lin H, Chuang K, Lin C, Yen H, Yeang C
PLoS Comput Biol
. 2017 Feb;
13(2):e1005367.
PMID: 28178267
Ambiguity in genetic codes exists in cases where certain stop codons are alternatively used to encode non-canonical amino acids. In selenoprotein transcripts, the UGA codon may either represent a translation...
8.
Wilson S, Wilkins A, Lin C, Lua R, Lichtarge O
Pac Symp Biocomput
. 2016 Nov;
22:336-347.
PMID: 27896987
Advances in cellular, molecular, and disease biology depend on the comprehensive characterization of gene interactions and pathways. Traditionally, these pathways are curated manually, limiting their efficient annotation and, potentially, reinforcing...
9.
Chou S, Wang C, Sintupisut N, Niou Z, Lin C, Li K, et al.
Sci Rep
. 2016 Jan;
6:19274.
PMID: 26786896
Allen Brain Atlas (ABA) provides a valuable resource of spatial/temporal gene expressions in mammalian brains. Despite rich information extracted from this database, current analyses suffer from several limitations. First, most...
10.
Swamy K, Lin C, Yen M, Wang C, Wang D
BMC Genomics
. 2014 Jun;
15:521.
PMID: 24965678
Background: Recent studies have demonstrated that antisense transcription is pervasive in budding yeasts and is conserved between Saccharomyces cerevisiae and S. paradoxus. While studies have examined antisense transcripts of S....