Daniel M Hardy
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Explore the profile of Daniel M Hardy including associated specialties, affiliations and a list of published articles.
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369
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Recent Articles
1.
Cormier N, Worsham A, Rich K, Hardy D
Int J Mol Sci
. 2024 Apr;
25(7).
PMID: 38612464
Immunodominant alloantigens in pig sperm membranes include 15 known gene products and a previously undiscovered r 20,000 sperm membrane-specific protein (SMA20). Here we characterize SMA20 and identify it as the...
2.
Ashton M, Worsham A, Strawn M, Fisher G, Perry C, Ferguson M, et al.
Int J Mol Sci
. 2023 Feb;
24(3).
PMID: 36768233
Correlating gene expression patterns with biomechanical properties of connective tissues provides insights into the molecular processes underlying the tissue growth and repair. Cadaveric specimens such as human knees are widely...
3.
Roberts E, Tardif S, Wright E, Platt 2nd R, Bradley R, Hardy D
Genome Biol
. 2022 Jul;
23(1):155.
PMID: 35821049
Background: Speciation genes contribute disproportionately to species divergence, but few examples exist, especially in vertebrates. Here we test whether Zan, which encodes the sperm acrosomal protein zonadhesin that mediates species-specific...
4.
Harakal J, Qiao H, Wheeler K, Rival C, Paul A, Hardy D, et al.
Front Immunol
. 2022 Jun;
13:809247.
PMID: 35693780
Continuous exposure of tissue antigen (Ag) to the autoantigen-specific regulatory T cells (Treg) is required to maintain Treg-dependent systemic tolerance. Thus, testis autoantigens, previously considered as sequestered, may not be...
5.
Cormier N, McGlone J, Leszyk J, Hardy D
PLoS One
. 2018 Jan;
13(1):e0190891.
PMID: 29342175
Sperm competence in animal fertilization requires the collective activities of numerous sperm-specific proteins that are typically alloimmunogenic in females. Consequently, sperm membrane alloantigens are potential targets for contraceptives that act...
6.
Tung K, Harakal J, Qiao H, Rival C, Li J, Paul A, et al.
J Clin Invest
. 2017 Feb;
127(3):1046-1060.
PMID: 28218625
Autoimmune responses to meiotic germ cell antigens (MGCA) that are expressed on sperm and testis occur in human infertility and after vasectomy. Many MGCA are also expressed as cancer/testis antigens...
7.
Tourville T, Shultz S, Vacek P, Knudsen E, Bernstein I, Tourville K, et al.
J Athl Train
. 2016 Jan;
51(1):47-56.
PMID: 26807868
Context: Women are 2 to 8 times more likely to sustain an anterior cruciate ligament (ACL) injury than men, and previous studies indicated an increased risk for injury during the...
8.
Hashemi J, Mansouri H, Chandrashekar N, Slauterbeck J, Hardy D, Beynnon B
J Orthop Res
. 2011 Jan;
29(7):993-1001.
PMID: 21246609
Anterior cruciate ligament (ACL) injury continues to be at the forefront of sports injury concerns because of its impact on quality of life and joint health prognosis. One strategy is...
9.
Hashemi J, Breighner R, Chandrashekar N, Hardy D, Chaudhari A, Shultz S, et al.
J Biomech
. 2010 Dec;
44(4):577-85.
PMID: 21144520
Considering that an athlete performs at-risk sports activities countless times throughout the course of his or her career prior to the instance of anterior cruciate ligament (ACL) injury, one may...
10.
Tardif S, Wilson M, Wagner R, Hunt P, Gertsenstein M, Nagy A, et al.
J Biol Chem
. 2010 Jun;
285(32):24863-70.
PMID: 20529856
Interaction of rapidly evolving molecules imparts species specificity to sperm-egg recognition in marine invertebrates, but it is unclear whether comparable interactions occur during fertilization in any vertebrate species. In mammals,...