Daniel H Arlow
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Explore the profile of Daniel H Arlow including associated specialties, affiliations and a list of published articles.
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15
Citations
3370
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Recent Articles
1.
Smith J, Nguyen B, Carlson R, Bertram J, Palluk S, Arlow D, et al.
ACS Synth Biol
. 2023 May;
12(6):1716-1726.
PMID: 37192389
Novel enzymatic methods are poised to become the dominant processes for de novo synthesis of DNA, promising functional, economic, and environmental advantages over the longstanding approach of phosphoramidite synthesis. Before...
2.
Barthel S, Palluk S, Hillson N, Keasling J, Arlow D
Genes (Basel)
. 2020 Jan;
11(1).
PMID: 31963235
Enzymatic oligonucleotide synthesis methods based on the template-independent polymerase terminal deoxynucleotidyl transferase (TdT) promise to enable the de novo synthesis of long oligonucleotides under mild, aqueous conditions. Intermediates with a...
3.
Palluk S, Arlow D, de Rond T, Barthel S, Kang J, Bector R, et al.
Nat Biotechnol
. 2018 Jun;
36(7):645-650.
PMID: 29912208
Oligonucleotides are almost exclusively synthesized using the nucleoside phosphoramidite method, even though it is limited to the direct synthesis of ∼200 mers and produces hazardous waste. Here, we describe an...
4.
Dror R, Mildorf T, Hilger D, Manglik A, Borhani D, Arlow D, et al.
Science
. 2015 Jun;
348(6241):1361-5.
PMID: 26089515
G protein-coupled receptors (GPCRs) relay diverse extracellular signals into cells by catalyzing nucleotide release from heterotrimeric G proteins, but the mechanism underlying this quintessential molecular signaling event has remained unclear....
5.
Dror R, Green H, Valant C, Borhani D, Valcourt J, Pan A, et al.
Nature
. 2013 Oct;
503(7475):295-9.
PMID: 24121438
The design of G-protein-coupled receptor (GPCR) allosteric modulators, an active area of modern pharmaceutical research, has proved challenging because neither the binding modes nor the molecular mechanisms of such drugs...
6.
Nygaard R, Zou Y, Dror R, Mildorf T, Arlow D, Manglik A, et al.
Cell
. 2013 Feb;
152(3):532-42.
PMID: 23374348
G-protein-coupled receptors (GPCRs) can modulate diverse signaling pathways, often in a ligand-specific manner. The full range of functionally relevant GPCR conformations is poorly understood. Here, we use NMR spectroscopy to...
7.
Zhang C, Srinivasan Y, Arlow D, Fung J, Palmer D, Zheng Y, et al.
Nature
. 2012 Dec;
492(7429):387-92.
PMID: 23222541
Protease-activated receptor 1 (PAR1) is the prototypical member of a family of G-protein-coupled receptors that mediate cellular responses to thrombin and related proteases. Thrombin irreversibly activates PAR1 by cleaving the...
8.
Kruse A, Hu J, Pan A, Arlow D, Rosenbaum D, Rosemond E, et al.
Nature
. 2012 Feb;
482(7386):552-6.
PMID: 22358844
Acetylcholine, the first neurotransmitter to be identified, exerts many of its physiological actions via activation of a family of G-protein-coupled receptors (GPCRs) known as muscarinic acetylcholine receptors (mAChRs). Although the...
9.
Dror R, Arlow D, Maragakis P, Mildorf T, Pan A, Xu H, et al.
Proc Natl Acad Sci U S A
. 2011 Oct;
108(46):18684-9.
PMID: 22031696
A third of marketed drugs act by binding to a G-protein-coupled receptor (GPCR) and either triggering or preventing receptor activation. Although recent crystal structures have provided snapshots of both active...
10.
Dror R, Pan A, Arlow D, Borhani D, Maragakis P, Shan Y, et al.
Proc Natl Acad Sci U S A
. 2011 Jul;
108(32):13118-23.
PMID: 21778406
How drugs bind to their receptors--from initial association, through drug entry into the binding pocket, to adoption of the final bound conformation, or "pose"--has remained unknown, even for G-protein-coupled receptor...