David W Borhani
Overview
Explore the profile of David W Borhani including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
1997
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Recent Articles
1.
Dror R, Mildorf T, Hilger D, Manglik A, Borhani D, Arlow D, et al.
Science
. 2015 Jun;
348(6241):1361-5.
PMID: 26089515
G protein-coupled receptors (GPCRs) relay diverse extracellular signals into cells by catalyzing nucleotide release from heterotrimeric G proteins, but the mechanism underlying this quintessential molecular signaling event has remained unclear....
2.
Dror R, Green H, Valant C, Borhani D, Valcourt J, Pan A, et al.
Nature
. 2013 Oct;
503(7475):295-9.
PMID: 24121438
The design of G-protein-coupled receptor (GPCR) allosteric modulators, an active area of modern pharmaceutical research, has proved challenging because neither the binding modes nor the molecular mechanisms of such drugs...
3.
Pan A, Borhani D, Dror R, Shaw D
Drug Discov Today
. 2013 Mar;
18(13-14):667-73.
PMID: 23454741
It is increasingly appreciated that the rates at which drugs associate with and dissociate from receptors--the binding kinetics--directly impact drug efficacy and safety. The molecular determinants of drug-receptor binding kinetics...
4.
Argiriadi M, Goedken E, Banach D, Borhani D, Burchat A, Dixon R, et al.
BMC Struct Biol
. 2012 Sep;
12:22.
PMID: 22995073
Background: Structure-based drug design (SBDD) can accelerate inhibitor lead design and optimization, and efficient methods including protein purification, characterization, crystallization, and high-resolution diffraction are all needed for rapid, iterative structure...
5.
Jensen M, Jogini V, Borhani D, Leffler A, Dror R, Shaw D
Science
. 2012 Apr;
336(6078):229-33.
PMID: 22499946
The mechanism of ion channel voltage gating-how channels open and close in response to voltage changes-has been debated since Hodgkin and Huxley's seminal discovery that the crux of nerve conduction...
6.
Borhani D, Shaw D
J Comput Aided Mol Des
. 2011 Dec;
26(1):15-26.
PMID: 22183577
Molecular dynamics simulations can now track rapid processes--those occurring in less than about a millisecond--at atomic resolution for many biologically relevant systems. These simulations appear poised to exert a significant...
7.
8.
Dror R, Arlow D, Maragakis P, Mildorf T, Pan A, Xu H, et al.
Proc Natl Acad Sci U S A
. 2011 Oct;
108(46):18684-9.
PMID: 22031696
A third of marketed drugs act by binding to a G-protein-coupled receptor (GPCR) and either triggering or preventing receptor activation. Although recent crystal structures have provided snapshots of both active...
9.
Dror R, Pan A, Arlow D, Borhani D, Maragakis P, Shan Y, et al.
Proc Natl Acad Sci U S A
. 2011 Jul;
108(32):13118-23.
PMID: 21778406
How drugs bind to their receptors--from initial association, through drug entry into the binding pocket, to adoption of the final bound conformation, or "pose"--has remained unknown, even for G-protein-coupled receptor...
10.
Borhani D
Science
. 2011 May;
332(6034):1149.
PMID: 21622711
Wolfe-Simon et al. (Research Articles, 3 June 2011, p. 1163; published online 2 December 2010) reported the discovery of an unusual bacterium, strain GFAJ-1, that can grow in the presence...