Daniel G Chawla
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Explore the profile of Daniel G Chawla including associated specialties, affiliations and a list of published articles.
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14
Citations
156
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Recent Articles
1.
Sparks R, Rachmaninoff N, Lau W, Hirsch D, Bansal N, Martins A, et al.
Nat Med
. 2024 Jul;
30(9):2461-2472.
PMID: 38961223
Immunological health has been challenging to characterize but could be defined as the absence of immune pathology. While shared features of some immune diseases and the concept of immunologic resilience...
2.
Chen X, Wang Y, Cappuccio A, Cheng W, Zamojski F, Nair V, et al.
Nat Comput Sci
. 2024 Jan;
3(9):805.
PMID: 38177788
No abstract available.
3.
Chen X, Wang Y, Cappuccio A, Cheng W, Zamojski F, Nair V, et al.
Nat Comput Sci
. 2023 Nov;
3(7):644-657.
PMID: 37974651
Resolving chromatin-remodeling-linked gene expression changes at cell-type resolution is important for understanding disease states. Here we describe MAGICAL (Multiome Accessibility Gene Integration Calling and Looping), a hierarchical Bayesian approach that...
4.
Sparks R, Rachmaninoff N, Hirsch D, Bansal N, Lau W, Martins A, et al.
Res Sq
. 2023 Mar;
PMID: 36993430
Monogenic diseases are often studied in isolation due to their rarity. Here we utilize multiomics to assess 22 monogenic immune-mediated conditions with age- and sex-matched healthy controls. Despite clearly detectable...
5.
Konstorum A, Mohanty S, Zhao Y, Melillo A, Vander Wyk B, Nelson A, et al.
Aging Cell
. 2023 Jan;
22(2):e13749.
PMID: 36656789
Platelets are uniquely positioned as mediators of not only hemostasis but also innate immunity. However, how age and geriatric conditions such as frailty influence platelet function during an immune response...
6.
Cappuccio A, Chawla D, Chen X, Rubenstein A, Cheng W, Mao W, et al.
Cell Syst
. 2022 Dec;
13(12):989-1001.e8.
PMID: 36549275
The identification of a COVID-19 host response signature in blood can increase the understanding of SARS-CoV-2 pathogenesis and improve diagnostic tools. Applying a multi-objective optimization framework to both massive public...
7.
Chawla D, Cappuccio A, Tamminga A, Sealfon S, Zaslavsky E, Kleinstein S
Cell Syst
. 2022 Dec;
13(12):974-988.e7.
PMID: 36549274
Identification of host transcriptional response signatures has emerged as a new paradigm for infection diagnosis. For clinical applications, signatures must robustly detect the pathogen of interest without cross-reacting with unintended...
8.
Smith K, Chawla D, Dhillon B, Ji Z, Vita R, van der Leest E, et al.
Sci Data
. 2022 Nov;
9(1):678.
PMID: 36347894
Recent advances in high-throughput experiments and systems biology approaches have resulted in hundreds of publications identifying "immune signatures". Unfortunately, these are often described within text, figures, or tables in a...
9.
Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination
Fourati S, Tomalin L, Mule M, Chawla D, Gerritsen B, Rychkov D, et al.
Nat Immunol
. 2022 Nov;
23(12):1777-1787.
PMID: 36316476
Several studies have shown that the pre-vaccination immune state is associated with the antibody response to vaccination. However, the generalizability and mechanisms that underlie this association remain poorly defined. Here,...
10.
Hagan T, Gerritsen B, Tomalin L, Fourati S, Mule M, Chawla D, et al.
Nat Immunol
. 2022 Nov;
23(12):1788-1798.
PMID: 36316475
Systems vaccinology has defined molecular signatures and mechanisms of immunity to vaccination. However, comparative analysis of immunity to different vaccines is lacking. We integrated transcriptional data of over 3,000 samples,...