Daniel D Oprian
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Explore the profile of Daniel D Oprian including associated specialties, affiliations and a list of published articles.
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35
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1092
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Recent Articles
1.
Kumar R, Matos J, Black B, Ellenburg W, Chen J, Patterson M, et al.
Biochemistry
. 2024 Oct;
63(21):2904-2915.
PMID: 39400323
In a continuing effort to understand reaction mechanisms of terpene synthases catalyzing initial anti-Markovnikov cyclization reactions, we solved the X-ray crystal structure of (+)-caryolan-1-ol synthase (CS) from , with and...
2.
Ellenburg W, Oprian D
Methods Enzymol
. 2024 Jun;
699:187-205.
PMID: 38942503
Terpene synthases (TS) transform achiral prenyl substrates into elaborate hydrocarbon scaffolds with multiple stereocenters through a series of cyclization reactions and carbon skeleton rearrangements. The reactions involve high-energy carbocation intermediates...
3.
Kumar R, Matos J, Black B, Ellenburg W, Chen J, Patterson M, et al.
bioRxiv
. 2024 May;
PMID: 38746203
In a continuing effort to understand reaction mechanisms of terpene synthases catalyzing initial anti-Markovnikov cyclization reactions, we solved the X-ray crystal structure of (+)-caryolan-1-ol synthase (CS) from , with and...
4.
Schiff W, Oprian D
Biochemistry
. 2023 Aug;
62(16):2472-2479.
PMID: 37531404
The monoterpene limonene is produced by the enzyme limonene synthase in one of the simplest terpene cyclization reactions. The enzyme can use linalyl diphosphate (LPP) and neryl diphosphate (NPP) as...
5.
Matos J, Kumar R, Ma A, Patterson M, Krauss I, Oprian D
Biochemistry
. 2020 Aug;
59(35):3271-3283.
PMID: 32786410
Most terpene synthase reactions follow Markovnikov rules for formation of high-energy carbenium ion intermediates. However, there are notable exceptions. For example, pentalenene synthase (PS) undergoes an initial anti-Markovnikov cyclization reaction...
6.
Morehouse B, Kumar R, Matos J, Yu Q, Bannister A, Malik K, et al.
ACS Chem Biol
. 2019 Aug;
14(9):2035-2043.
PMID: 31433159
Linalyl diphosphate (LPP) is the postulated intermediate in the enzymatic cyclization of monoterpenes catalyzed by terpene synthases. LPP is considered an obligate intermediate due to the conformationally restrictive -C2-C3 double...
7.
Ozdeslik R, Olinski L, Trieu M, Oprian D, Oancea E
Proc Natl Acad Sci U S A
. 2019 May;
116(23):11508-11517.
PMID: 31097585
Opsins form a family of light-activated, retinal-dependent, G protein-coupled receptors (GPCRs) that serve a multitude of visual and nonvisual functions. Opsin 3 (OPN3 or encephalopsin), initially identified in the brain,...
8.
Kumar R, Morehouse B, Fofana J, Trieu M, Zhou D, Lorenz M, et al.
J Biol Chem
. 2017 Nov;
292(52):21578-21589.
PMID: 29118188
RhoGC is a fusion protein from the aquatic fungus , combining a type I rhodopsin domain with a guanylyl cyclase domain. It has generated excitement as an optogenetics tool for...
9.
Lamarche L, Kumar R, Trieu M, Devine E, Cohen-Abeles L, Theobald D, et al.
Biochemistry
. 2017 Oct;
56(43):5812-5822.
PMID: 28976747
RhoPDE is a type I rhodopsin/phosphodiesterase gene fusion product from the choanoflagellate Salpingoeca rosetta. The gene was discovered around the time that a similar type I rhodopsin/guanylyl cyclase fusion protein,...
10.
Trieu M, Devine E, Lamarche L, Ammerman A, Greco J, Birge R, et al.
J Biol Chem
. 2017 May;
292(25):10379-10389.
PMID: 28473465
RhoGC is a rhodopsin (Rho)-guanylyl cyclase (GC) gene fusion molecule that is central to zoospore phototaxis in the aquatic fungus It has generated considerable excitement because of its demonstrated potential...