Benjamin R Morehouse
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Explore the profile of Benjamin R Morehouse including associated specialties, affiliations and a list of published articles.
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19
Citations
921
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Recent Articles
1.
Ednacot E, Nabhani A, Dinh D, Morehouse B
Pharmacol Ther
. 2024 Apr;
258:108653.
PMID: 38679204
Cyclic nucleotides are important signaling molecules that play many critical physiological roles including controlling cell fate and development, regulation of metabolic processes, and responding to changes in the environment. Cyclic...
2.
3.
Nabhani A, Morehouse B
Cell Host Microbe
. 2023 Sep;
31(9):1420-1422.
PMID: 37708847
Viral strategies to lyse host microbes can sometimes involve just a single gene, although the mechanism of action can be hard to discern. In Science, Orta et al. present structures...
4.
Li Y, Slavik K, Toyoda H, Morehouse B, de Oliveira Mann C, Elek A, et al.
Cell
. 2023 Jun;
186(15):3261-3276.e20.
PMID: 37379839
Cyclic GMP-AMP synthase (cGAS) is an enzyme in human cells that controls an immune response to cytosolic DNA. Upon binding DNA, cGAS synthesizes a nucleotide signal 2'3'-cGAMP that activates STING-dependent...
5.
Morehouse B
Curr Opin Microbiol
. 2023 Apr;
73:102295.
PMID: 37011504
The innate immune system is the first line of defense against microbial pathogens. Many of the features of eukaryotic innate immunity have long been viewed as lineage-specific innovations, evolved to...
6.
Li Y, Slavik K, Morehouse B, de Oliveira Mann C, Mears K, Liu J, et al.
bioRxiv
. 2023 Mar;
PMID: 36865129
cGAS (cyclic GMP-AMP synthase) is an enzyme in human cells that controls an immune response to cytosolic DNA. Upon binding DNA, cGAS synthesizes a nucleotide signal 2'3'-cGAMP that activates the...
7.
Leavitt A, Yirmiya E, Amitai G, Lu A, Garb J, Herbst E, et al.
Nature
. 2022 Sep;
611(7935):326-331.
PMID: 36174646
The Toll/interleukin-1 receptor (TIR) domain is a key component of immune receptors that identify pathogen invasion in bacteria, plants and animals. In the bacterial antiphage system Thoeris, as well as...
8.
Morehouse B, Yip M, Keszei A, McNamara-Bordewick N, Shao S, Kranzusch P
Nature
. 2022 Jul;
608(7924):803-807.
PMID: 35859168
Stimulator of interferon genes (STING) is an antiviral signalling protein that is broadly conserved in both innate immunity in animals and phage defence in prokaryotes. Activation of STING requires its...
9.
Hobbs S, Wein T, Lu A, Morehouse B, Schnabel J, Leavitt A, et al.
Nature
. 2022 Apr;
605(7910):522-526.
PMID: 35395152
The cyclic oligonucleotide-based antiphage signalling system (CBASS) and the pyrimidine cyclase system for antiphage resistance (Pycsar) are antiphage defence systems in diverse bacteria that use cyclic nucleotide signals to induce...
10.
Tal N, Morehouse B, Millman A, Stokar-Avihail A, Avraham C, Fedorenko T, et al.
Cell
. 2021 Oct;
184(23):5728-5739.e16.
PMID: 34644530
The cyclic pyrimidines 3',5'-cyclic cytidine monophosphate (cCMP) and 3',5'-cyclic uridine monophosphate (cUMP) have been reported in multiple organisms and cell types. As opposed to the cyclic nucleotides 3',5'-cyclic adenosine monophosphate...