Daniel Christ
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Explore the profile of Daniel Christ including associated specialties, affiliations and a list of published articles.
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91
Citations
2652
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Recent Articles
1.
Chambers C, Watakul S, Schofield P, Howell A, Zhu J, Tran A, et al.
Sci Adv
. 2025 Mar;
11(11):eadq4416.
PMID: 40073121
Pancreatic cancer (PC) is a highly metastatic malignancy. More than 80% of patients with PC present with advanced-stage disease, preventing potentially curative surgery. The neuropeptide Y (NPY) system, best known...
2.
Stander S, Reboul C, Le S, Williams D, Chandler P, Costa M, et al.
Nat Commun
. 2025 Mar;
16(1):2275.
PMID: 40055307
The enzyme glutamate decarboxylase (GAD) produces the neurotransmitter GABA, using pyridoxal-5'-phosphate (PLP). GAD exists as two isoforms, GAD65 and GAD67. Only GAD65 acts as a major autoantigen, frequently implicated in...
3.
Witcher C, Christ D, Sudweeks J, Layman C, Perez M
J Safety Res
. 2025 Feb;
91:303-313.
PMID: 39998532
Introduction: The degree to which hydroplaning occurs in real-world conditions is not entirely known. Naturalistic driving data can be helpful in addressing some of the limitations of existing data sources...
4.
Ruggiero E, Marusic M, Zanin I, Pena Martinez C, Christ D, Plavec J, et al.
Nucleic Acids Res
. 2025 Jan;
53(2).
PMID: 39817511
i-Motifs (iMs) are quadruplex nucleic acid conformations that form in cytosine-rich regions. Because of their acidic pH dependence, iMs were thought to form only in vitro. The recent development of...
5.
Mazigi O, Langley D, Henry J, Burnett D, Sobti M, Walker G, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(1):e2417544121.
PMID: 39746041
The emergence of SARS-CoV-2 variants of concern (VOCs) has greatly diminished the neutralizing activity of previously FDA-approved monoclonal antibodies (mAbs), including that of antibody cocktails and of first-generation broadly neutralizing...
6.
Dvorscek A, McKenzie C, Staheli V, Ding Z, White J, Fabb S, et al.
Immunity
. 2024 Sep;
57(10):2433-2452.e7.
PMID: 39305904
Existing antibodies (Abs) have varied effects on humoral immunity during subsequent infections. Here, we leveraged in vivo systems that allow precise control of antigen-specific Abs and B cells to examine...
7.
Pena Martinez C, Zeraati M, Rouet R, Mazigi O, Henry J, Gloss B, et al.
EMBO J
. 2024 Aug;
43(20):4786-4804.
PMID: 39210146
DNA i-motif structures are formed in the nuclei of human cells and are believed to provide critical genomic regulation. While the existence, abundance, and distribution of i-motif structures in human...
8.
Mohamed S, Schofield P, McCalmont H, Moles E, Friedrich K, Kavallaris M, et al.
Int J Biol Macromol
. 2023 Oct;
254(Pt 1):127596.
PMID: 37898250
Philadelphia-like acute lymphoblastic leukemia (Ph-like ALL) is an aggressive B-ALL malignancy associated with high rates of relapse and inferior survival rate. While targeted treatments against the cell surface proteins CD22...
9.
Schofield P, Taylor A, Rihon J, Pena Martinez C, Zinn S, Mattelaer C, et al.
Nucleic Acids Res
. 2023 Jul;
51(15):7736-7748.
PMID: 37439359
Nucleic acids not only form the basis of heredity, but are increasingly a source of novel nano-structures, -devices and drugs. This has spurred the development of chemically modified alternatives (xeno...
10.
Logan G, Mietzsch M, Khandekar N, DSilva A, Anderson D, Mandwie M, et al.
Mol Ther
. 2023 Apr;
31(7):1979-1993.
PMID: 37012705
Success in the treatment of infants with spinal muscular atrophy (SMA) underscores the potential of vectors based on adeno-associated virus (AAV). However, a major obstacle to the full realization of...