David B Langley
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Explore the profile of David B Langley including associated specialties, affiliations and a list of published articles.
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46
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923
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Recent Articles
1.
Mazigi O, Langley D, Henry J, Burnett D, Sobti M, Walker G, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(1):e2417544121.
PMID: 39746041
The emergence of SARS-CoV-2 variants of concern (VOCs) has greatly diminished the neutralizing activity of previously FDA-approved monoclonal antibodies (mAbs), including that of antibody cocktails and of first-generation broadly neutralizing...
2.
Rouet R, Henry J, Johansen M, Sobti M, Balachandran H, Langley D, et al.
Nat Commun
. 2023 Feb;
14(1):687.
PMID: 36755042
Emerging variants of concern (VOCs) are threatening to limit the effectiveness of SARS-CoV-2 monoclonal antibodies and vaccines currently used in clinical practice; broadly neutralizing antibodies and strategies for their identification...
3.
Langley D, Schofield P, Nevoltris D, Jackson J, Jackson K, Peters T, et al.
Proc Natl Acad Sci U S A
. 2022 Jul;
119(28):e2123212119.
PMID: 35867757
Humans lack the capacity to produce the Galα1-3Galβ1-4GlcNAc (α-gal) glycan, and produce anti-α-gal antibodies upon exposure to the carbohydrate on a diverse set of immunogens, including commensal gut bacteria, malaria...
4.
Langley D, Schofield P, Jackson J, Herzog H, Christ D
Neuropeptides
. 2022 Feb;
92:102231.
PMID: 35180645
Neuropeptide Y (NPY), peptide YY (PYY) and pancreatic polypeptide (PP) form the evolutionarily conserved pancreatic polypeptide family. While the fold is widely utilized in nature, crystal structures remain elusive, particularly...
5.
Burnett D, Jackson K, Langley D, Aggrawal A, Stella A, Johansen M, et al.
Immunity
. 2021 Nov;
54(12):2908-2921.e6.
PMID: 34788600
Viral mutations are an emerging concern in reducing SARS-CoV-2 vaccination efficacy. Second-generation vaccines will need to elicit neutralizing antibodies against sites that are evolutionarily conserved across the sarbecovirus subgenus. Here,...
6.
Maeda F, van Haaren J, Langley D, Christ D, Andrews N, Song W
Elife
. 2021 Oct;
10.
PMID: 34704555
B-cell receptor (BCR)-mediated antigen internalization and presentation are essential for humoral memory immune responses. Antigen encountered by B-cells is often tightly associated with the surface of pathogens and/or antigen-presenting cells....
7.
Rouet R, Mazigi O, Walker G, Langley D, Sobti M, Schofield P, et al.
MAbs
. 2021 May;
13(1):1922134.
PMID: 34024246
Antibodies against coronavirus spike protein potently protect against infection and disease, but whether such protection can be extended to variant coronaviruses is unclear. This is exemplified by a set of...
8.
Cagdas D, Mayr D, Baris S, Worley L, Langley D, Metin A, et al.
J Clin Immunol
. 2021 Apr;
41(6):1272-1290.
PMID: 33929673
Biallelic inactivating mutations in IL21R causes a combined immunodeficiency that is often complicated by cryptosporidium infections. While eight IL-21R-deficient patients have been reported previously, the natural course, immune characteristics of...
9.
Burnett D, Schofield P, Langley D, Jackson J, Bourne K, Wilson E, et al.
Proc Natl Acad Sci U S A
. 2020 Aug;
117(36):22341-22350.
PMID: 32855302
Conformational diversity and self-cross-reactivity of antigens have been correlated with evasion from neutralizing antibody responses. We utilized single cell B cell sequencing, biolayer interferometry and X-ray crystallography to trace mutation...
10.
Singh M, Jackson K, Wang J, Schofield P, Field M, Koppstein D, et al.
Cell
. 2020 Feb;
180(5):878-894.e19.
PMID: 32059783
Pathogenic autoantibodies arise in many autoimmune diseases, but it is not understood how the cells making them evade immune checkpoints. Here, single-cell multi-omics analysis demonstrates a shared mechanism with lymphoid...