Daniel C Lim
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Explore the profile of Daniel C Lim including associated specialties, affiliations and a list of published articles.
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8
Citations
130
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Recent Articles
1.
Zhang T, Cepauskas A, Nadieina A, Thureau A, Coppieters t Wallant K, Martens C, et al.
Nature
. 2024 Oct;
635(8039):728-735.
PMID: 39415022
Eukaryotic innate immune systems use pattern recognition receptors to sense infection by detecting pathogen-associated molecular patterns, which then triggers an immune response. Bacteria have similarly evolved immunity proteins that sense...
2.
Connelly G, Kirkland O, Bohannon S, Lim D, Wilson R, Richards E, et al.
Cell Rep Methods
. 2022 Aug;
2(8):100273.
PMID: 35942328
Neutralizing antibody (NAb) titer is a key biomarker of protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but point-of-care methods for assessing NAb titer are not widely available....
3.
Ryu S, Park J, Ham Y, Lim D, Kwiatkowski N, Kim D, et al.
J Med Chem
. 2022 Jan;
65(3):1915-1932.
PMID: 35029981
The polo-box domain (PBD) of Plk1 is a promising target for cancer therapeutics. We designed and synthesized novel phosphorylated macrocyclic peptidomimetics targeting PBD based on acyclic phosphopeptide PMQSpTPL. The inhibitory...
4.
Lim D, Joukov V, Yaffe M
Mol Cell Oncol
. 2020 Nov;
7(6):1832419.
PMID: 33235921
Cell-cycle dependent redox changes result in increased protein oxidation in mitotic cells. We show that oxidative modifications of a conserved cysteine residue within Aurora A kinase (AURKA) can promote its...
5.
Lim D, Joukov V, Rettenmaier T, Kumagai A, Dunphy W, Wells J, et al.
Sci Signal
. 2020 Jul;
13(641).
PMID: 32694171
Cell cycle-dependent redox changes can mediate transient covalent modifications of cysteine thiols to modulate the activities of regulatory kinases and phosphatases. Our previously reported finding that protein cysteine oxidation is...
6.
Patterson J, Joughin B, van de Kooij B, Lim D, Lauffenburger D, Yaffe M
Cell Syst
. 2019 Feb;
8(2):163-167.e2.
PMID: 30797774
Although elevated levels of reactive oxygen species (ROS) have been observed in cancer cells and cancer cells aberrantly proliferate, it is not known whether the level of reactive oxygen species...
7.
Lim D, Cooke B, Doerig C, Saeij J
Int J Parasitol
. 2011 Dec;
42(1):21-32.
PMID: 22154850
Some apicomplexan parasites have evolved distinct protein kinase families to modulate host cell structure and function. Toxoplasma gondii rhoptry protein kinases and pseudokinases are involved in virulence and modulation of...
8.
Gretes M, Lim D, de Castro L, Jensen S, Kang S, Lee K, et al.
J Mol Biol
. 2009 Apr;
389(2):289-305.
PMID: 19332077
Beta-lactamase inhibitory protein (BLIP) binds a variety of beta-lactamase enzymes with wide-ranging specificity. Its binding mechanism and interface interactions are a well-established model system for the characterization of protein-protein interactions....