Toxoplasma and Plasmodium Protein Kinases: Roles in Invasion and Host Cell Remodelling

Overview

Journal Int J Parasitol

Specialty Parasitology

Date 2011 Dec 14

PMID 22154850

Citations 38

Authors

Daniel C Lim

Brian M Cooke

Christian Doerig

Jeroen P J Saeij

Affiliations

Soon will be listed here.

Abstract

Some apicomplexan parasites have evolved distinct protein kinase families to modulate host cell structure and function. Toxoplasma gondii rhoptry protein kinases and pseudokinases are involved in virulence and modulation of host cell signalling. The proteome of Plasmodium falciparum contains a family of putative kinases called FIKKs, some of which are exported to the host red blood cell and might play a role in erythrocyte remodelling. In this review we will discuss kinases known to be critical for host cell invasion, intracellular growth and egress, focusing on (i) calcium-dependent protein kinases and (ii) the secreted kinases that are unique to Toxoplasma (rhoptry protein kinases and pseudokinases) and Plasmodium (FIKKs).

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