Daniel A Tennant
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Explore the profile of Daniel A Tennant including associated specialties, affiliations and a list of published articles.
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59
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2940
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Recent Articles
1.
Vera-Siguenza E, Rana H, Nashebi R, Cloete I, Kluvckova K, Spill F, et al.
Bull Math Biol
. 2025 Mar;
87(4):53.
PMID: 40080323
The succinate dehydrogenase (SDH) is a four-subunit enzyme complex (SDH-a, SDH-b, SDH-c, and SDH-d) central to cell carbon metabolism. The SDH bridges the tricarboxylic acid cycle to the electron transport...
2.
Hlozkova K, Vasylkivska M, Boufersaoui A, Marzullo B, Kolarik M, Alquezar-Artieda N, et al.
Cancer Lett
. 2024 Sep;
605:217242.
PMID: 39270769
Tumor cells often adapt to amino acid deprivation through metabolic rewiring, compensating for the loss with alternative amino acids/substrates. We have described such a scenario in leukemic cells treated with...
3.
Bishop E, Gudgeon N, Fulton-Ward T, Stavrou V, Roberts J, Boufersaoui A, et al.
Sci Signal
. 2024 Apr;
17(833):eadg5678.
PMID: 38652761
Upon activation, T cells undergo metabolic reprogramming to meet the bioenergetic demands of clonal expansion and effector function. Because dysregulated T cell cytokine production and metabolic phenotypes coexist in chronic...
4.
Cuozzo F, Viloria K, Shilleh A, Nasteska D, Frazer-Morris C, Tong J, et al.
Cell Rep
. 2024 Apr;
43(4):114047.
PMID: 38607916
Using C glucose labeling coupled to gas chromatography-mass spectrometry and 2D H-C heteronuclear single quantum coherence NMR spectroscopy, we have obtained a comparative high-resolution map of glucose fate underpinning β...
5.
Clayton S, Lockwood C, ONeil J, Daley K, Hain S, Abdelmottaleb D, et al.
Discov Immunol
. 2024 Apr;
2(1):kyad027.
PMID: 38567068
Synthetic glucocorticoids are used to treat many chronic and acute inflammatory conditions. Frequent adverse effects of prolonged exposure to glucocorticoids include disturbances of glucose homeostasis caused by changes in glucose...
6.
Ravasz D, Bui D, Nazarian S, Pallag G, Karnok N, Roberts J, et al.
Sci Rep
. 2024 Jan;
14(1):1729.
PMID: 38242919
Anoxia halts oxidative phosphorylation (OXPHOS) causing an accumulation of reduced compounds in the mitochondrial matrix which impedes dehydrogenases. By simultaneously measuring oxygen concentration, NADH autofluorescence, mitochondrial membrane potential and ubiquinone...
7.
Lukes Jr J, Potuckova E, Alquezar-Artieda N, Hermanova I, Kosanovic S, Hlozkova K, et al.
Hemasphere
. 2023 Aug;
7(9):e946.
PMID: 37637992
No abstract available.
8.
Vellama H, Eskla K, Eichelmann H, Huva A, Tennant D, Thakker A, et al.
Free Radic Biol Med
. 2023 Jul;
208:1-12.
PMID: 37506952
Heritable renal cancer syndromes (RCS) are associated with numerous chromosomal alterations including inactivating mutations in von Hippel-Lindau (VHL) gene. Here we identify a novel aspect of the phenotype in VHL-deficient...
9.
Abukwaik R, Vera-Siguenza E, Tennant D, Spill F
J Theor Biol
. 2023 Jun;
572:111562.
PMID: 37348784
Chemotherapeutic drugs are used to treat almost all types of cancer, but the intended response, i.e., elimination, is often incomplete, with a subset of cancer cells resisting treatment. Two critical...
10.
Gudgeon N, Giles H, Bishop E, Fulton-Ward T, Escribano-Gonzalez C, Munford H, et al.
Blood Adv
. 2023 Jun;
7(20):6035-6047.
PMID: 37276076
T cells demonstrate impaired function in multiple myeloma (MM) but suppressive mechanisms in the bone marrow microenvironment remain poorly defined. We observe that bone marrow CD8+ T-cell function is decreased...