Dana Avrahami
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Explore the profile of Dana Avrahami including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
875
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Recent Articles
1.
Bahl V, Rifkind R, Waite E, Hamdan Z, May C, Manduchi E, et al.
Sci Transl Med
. 2025 Jan;
17(779):eadi6148.
PMID: 39742505
Elevated glucagon concentrations have been reported in patients with type 2 diabetes (T2D). A critical role for α cell-intrinsic mechanisms in regulating glucagon secretion was previously established through genetic manipulation...
2.
Waite E, Tigue M, Yu M, Lahori D, Kelly K, May C, et al.
Diabetes
. 2024 Nov;
74(3):332-342.
PMID: 39571094
Article Highlights: Current mouse models for assessing islet function in vivo are limited due to unstable and variable hyperglycemia and/or high morbidity. We derived the IsletTester mouse to address these...
3.
Unterman I, Avrahami D, Katsman E, Triche Jr T, Glaser B, Berman B
Genome Biol
. 2024 Jul;
25(1):182.
PMID: 38978142
No abstract available.
4.
Unterman I, Avrahami D, Katsman E, Triche Jr T, Glaser B, Berman B
Genome Biol
. 2024 Jun;
25(1):151.
PMID: 38858759
Deconvolution methods infer quantitative cell type estimates from bulk measurement of mixed samples including blood and tissue. DNA methylation sequencing measures multiple CpGs per read, but few existing deconvolution methods...
5.
Patra M, Klochendler A, Condiotti R, Kaffe B, Elgavish S, Drawshy Z, et al.
Nucleic Acids Res
. 2024 Apr;
52(11):6298-6316.
PMID: 38682582
Senescent cells can influence the function of tissues in which they reside, and their propensity for disease. A portion of adult human pancreatic beta cells express the senescence marker p16,...
6.
Higazi A, Maraga E, Baraghithy S, Udi S, Azar S, Saada A, et al.
iScience
. 2024 Feb;
27(2):108802.
PMID: 38318380
Inflammation is consistently linked to dysmetabolism. In transgenic mice (Def) model the neutrophilic peptide, alpha defensin, proved atherogenic. This phenotype occurred despite favorable cholesterol and glucose levels, and lower body...
7.
Riahi Y, Kogot-Levin A, Kadosh L, Agranovich B, Malka A, Assa M, et al.
Diabetologia
. 2023 Jul;
66(10):1925-1942.
PMID: 37480416
Aim/hypothesis: Hyperglycaemia is associated with alpha cell dysfunction, leading to dysregulated glucagon secretion in type 1 and type 2 diabetes; however, the mechanisms involved are still elusive. The nutrient sensor...
8.
Furth-Lavi J, Hija A, Tornovsky-Babeay S, Mazouz A, Dahan T, Stolovich-Rain M, et al.
Cell Rep
. 2022 Nov;
41(9):111719.
PMID: 36450253
Diabetogenic ablation of beta cells in mice triggers a regenerative response whereby surviving beta cells proliferate and euglycemia is regained. Here, we identify and characterize heterogeneity in response to beta...
9.
Dai X, Camunas-Soler J, Briant L, Dos Santos T, Spigelman A, Walker E, et al.
Cell Metab
. 2022 Feb;
34(2):256-268.e5.
PMID: 35108513
In diabetes, glucagon secretion from pancreatic α cells is dysregulated. The underlying mechanisms, and whether dysfunction occurs uniformly among cells, remain unclear. We examined α cells from human donors and...
10.
Tornovsky-Babeay S, Weinberg-Corem N, Ben-Haroush Schyr R, Avrahami D, Lavi J, Feleke E, et al.
Diabetologia
. 2021 Feb;
64(5):1133-1143.
PMID: 33558985
Aims/hypothesis: Acute hyperglycaemia stimulates pancreatic beta cell proliferation in the mouse whereas chronic hyperglycaemia appears to be toxic. We hypothesise that this toxic effect is mediated by increased beta cell...