Damian Houde
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Explore the profile of Damian Houde including associated specialties, affiliations and a list of published articles.
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28
Citations
1091
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Recent Articles
1.
Sun Y, Houde D, Iacob R, Baird J, Swift R, Holliday M, et al.
Anal Chem
. 2025 Feb;
97(8):4329-4340.
PMID: 39969248
Characterizing protein-ligand interactions is crucial to understanding cellular metabolism and guiding drug discovery and development. Herein, we explore complementing hydrogen/deuterium exchange mass spectrometry (HDX-MS) with a recently developed Fenton chemistry-based...
2.
Choi B, Han C, LaRochelle J, Pitsawong W, Houde D
J Am Soc Mass Spectrom
. 2024 Nov;
35(12):2785-2789.
PMID: 39495757
Rapid equilibrium dialysis (RED) is predominantly used for the characterization of drug absorption, distribution, metabolism, and excretion (ADME) properties in plasma and biological fluids. We describe herein improvements in the...
3.
Code C, Qiu D, Solovyov I, Lee J, Shin H, Roland C, et al.
J Am Chem Soc
. 2023 Oct;
145(44):23925-23938.
PMID: 37883679
Protein glycosylation is a common post-translational modification on extracellular proteins. The conformational dynamics of several glycoproteins have been characterized by hydrogen/deuterium exchange mass spectrometry (HDX-MS). However, it is, in most...
4.
Dooley K, McConnell R, Xu K, Lewis N, Haupt S, Youniss M, et al.
Mol Ther
. 2021 Jan;
29(5):1729-1743.
PMID: 33484965
Extracellular vesicles (EVs) are an important intercellular communication system facilitating the transfer of macromolecules between cells. Delivery of exogenous cargo tethered to the EV surface or packaged inside the lumen...
5.
Masson G, Burke J, Ahn N, Anand G, Borchers C, Brier S, et al.
Nat Methods
. 2019 Jun;
16(7):595-602.
PMID: 31249422
Hydrogen deuterium exchange mass spectrometry (HDX-MS) is a powerful biophysical technique being increasingly applied to a wide variety of problems. As the HDX-MS community continues to grow, adoption of best...
6.
Pawlowski J, Bajardi-Taccioli A, Houde D, Feschenko M, Carlage T, Kaltashov I
J Pharm Biomed Anal
. 2018 Jan;
151:133-144.
PMID: 29324282
Monoclonal antibodies (mAbs) are the fastest growing class of biopharmaceuticals. The specific therapeutic tasks vary among different mAbs, which may include neutralization of soluble targets, activation of cytotoxic pathways, targeted...
7.
Chen T, Sazinsky S, Houde D, DiLillo D, Bird J, Li K, et al.
J Mol Biol
. 2017 Jul;
429(16):2528-2541.
PMID: 28694069
The binding of human IgG1 to human Fc gamma receptors (hFcγRs) is highly sensitive to the presence of a single N-linked glycosylation site at asparagine 297 of the Fc, with...
8.
Weiss 4th W, Gabrielson J, Al-Azzam W, Chen G, Davis D, Das T, et al.
J Pharm Sci
. 2016 Oct;
105(12):3465-3470.
PMID: 27743675
Characterization of the higher order structure (HOS) of protein-based biopharmaceutical products is an important aspect of their development. Opinions vary about how best to apply biophysical methods, in which contexts...
9.
Inouye H, Houde D, Temel D, Makowski L
J Pharm Sci
. 2016 Sep;
105(11):3278-3289.
PMID: 27637321
Characterization of immunoglobulin solutions at high concentrations represents a significant challenge. A current trend in the biopharmaceutical industry is to manufacture highly concentrated drug products, which can be used to...
10.
E Nazari Z, van de Weert M, Bou-Assaf G, Houde D, Weiskopf A, Rand K
J Pharm Sci
. 2016 Sep;
105(11):3269-3277.
PMID: 27578543
Hydrogen deuterium exchange coupled to mass spectrometry (HDX-MS) has become an established method for analysis of protein higher order structure. Here, we use HDX-MS methodology based on manual solid-phase extraction...