Steven A Berkowitz
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Explore the profile of Steven A Berkowitz including associated specialties, affiliations and a list of published articles.
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18
Citations
716
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Recent Articles
1.
Larson N, Bou-Assaf G, Laue T, Berkowitz S
Anal Biochem
. 2024 Jul;
694:115617.
PMID: 39019206
Data are presented demonstrating that absorbance detection can be used during high-speed sedimentation velocity analytical ultracentrifugation (hs-SV-AUC) experiments to characterize the size distribution of adeno-associated virus (AAV) drug products accurately....
2.
Berkowitz S, Larson N, Bou-Assaf G, Laue T
Anal Biochem
. 2024 Feb;
689:115482.
PMID: 38342199
Simulated SV-AUC data for an adeno-associated virus (AAV) sample consisting of four components having closely spaced sedimentation coefficients were used to develop a high-speed protocol that optimized the size distribution...
3.
Berkowitz S, Laue T
Anal Biochem
. 2021 Jul;
631:114306.
PMID: 34274312
Analytical ultracentrifugation (AUC) provides the most widely applicable, precise, and accurate means for characterizing solution hydrodynamic and thermodynamic properties. While generally useful, boundary sedimentation velocity AUC (SV-AUC) analysis has become...
4.
Houde D, Bou-Assaf G, Berkowitz S
J Am Soc Mass Spectrom
. 2017 Feb;
28(5):840-849.
PMID: 28194741
Introduction of a chemical change to one or more amino acids in a protein's polypeptide chain can result in various effects on its higher-order structure (HOS) and biophysical behavior (or...
5.
Iacob R, Bou-Assaf G, Makowski L, Engen J, Berkowitz S, Houde D
J Pharm Sci
. 2013 Oct;
102(12):4315-29.
PMID: 24136070
To determine how structural changes in antibodies are connected with aggregation, the structural areas of an antibody prone to and/or impacted by aggregation must be identified. In this work, the...
6.
Kulczyk A, Akabayov B, Lee S, Bostina M, Berkowitz S, Richardson C
J Biol Chem
. 2012 Sep;
287(46):39050-60.
PMID: 22977246
Synthesis of the leading DNA strand requires the coordinated activity of DNA polymerase and DNA helicase, whereas synthesis of the lagging strand involves interactions of these proteins with DNA primase....
7.
Berkowitz S, Engen J, Mazzeo J, Jones G
Nat Rev Drug Discov
. 2012 Jun;
11(7):527-40.
PMID: 22743980
Biologics such as monoclonal antibodies are much more complex than small-molecule drugs, which raises challenging questions for the development and regulatory evaluation of follow-on versions of such biopharmaceutical products (also...
8.
Houde D, Berkowitz S
J Pharm Sci
. 2012 Jan;
101(5):1688-700.
PMID: 22271461
A long lasting recombinant factor IX -Fc fusion protein (rFIX-Fc) is being developed for the treatment of hemophilia B and is currently in late stage clinical investigation. By limiting injection...
9.
Li H, Bai S, Wei J, Berkowitz S, Brader M
J Pharm Sci
. 2011 Jun;
100(11):4597-606.
PMID: 21678428
There is significant scope for more meaningful evaluation of higher-order structure in defining the quality of biopharmaceutical products [Bush L. 2010. Biopharm Int 23(4):14]. We have used isothermal titration calorimetry...
10.
Houde D, Berkowitz S, Engen J
J Pharm Sci
. 2011 Apr;
100(6):2071-86.
PMID: 21491437
The function, efficacy, and safety of protein biopharmaceuticals are tied to their three-dimensional structure. The analysis and verification of this higher-order structure are critical in demonstrating manufacturing consistency and in...