Dagmar Gotthardt
Overview
Explore the profile of Dagmar Gotthardt including associated specialties, affiliations and a list of published articles.
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Articles
36
Citations
808
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Recent Articles
1.
Karjalainen A, Witalisz-Siepracka A, Prchal-Murphy M, Martin D, Sternberg F, Krunic M, et al.
Cell Mol Life Sci
. 2025 Mar;
82(1):98.
PMID: 40025196
Tyrosine kinase 2 (TYK2) deficiency and loss or inhibition of kinase activity in men and mice leads to similar immune compromised phenotypes, predominantly through impairment of interferon (IFN) and interleukin...
2.
Buri M, Shoeb M, Bykov A, Repiscak P, Baik H, Dupanovic A, et al.
Cancer Immunol Res
. 2024 Dec;
13(3):430-446.
PMID: 39642167
The term cancer immunoediting describes the dual role by which the immune system can suppress and promote tumor growth and is divided into three phases: elimination, equilibrium, and escape. The...
3.
Chen J, Sobecki M, Krzywinska E, Thierry K, Masmoudi M, Nagarajan S, et al.
EMBO Mol Med
. 2024 Oct;
16(12):3033-3056.
PMID: 39478152
A hallmark feature of pancreatic ductal adenocarcinoma (PDAC) is massive intratumoral fibrosis, designated as desmoplasia. Desmoplasia is characterized by the expansion of cancer-associated fibroblasts (CAFs) and a massive increase in...
4.
Trifinopoulos J, List J, Klampfl T, Klein K, Prchal-Murphy M, Witalisz-Siepracka A, et al.
Haematologica
. 2024 Oct;
PMID: 39385738
Despite major therapeutic advances in the treatment of acute lymphoblastic leukemia (ALL), resistances and long-term toxicities still pose significant challenges. Cyclins and their associated cyclin-dependent kinases are one focus of...
5.
List J, Gattringer J, Huszarek S, Marinovic S, Neubauer H, Kudweis P, et al.
Biomed Pharmacother
. 2024 Jul;
177:117057.
PMID: 38976957
Cyclotides are head-to-tail cyclized peptides with a unique cystine-knot motif. Their structure provides exceptional resistance against enzymatic, chemical, or thermal degradation compared to other peptides. Peptide-based therapeutics promise high specificity,...
6.
Nelius E, Fan Z, Sobecki M, Krzywinska E, Nagarajan S, Ferapontova I, et al.
Life Sci Alliance
. 2024 Jun;
7(9).
PMID: 38876796
Innate lymphoid cells (ILCs) are critical for intestinal adaptation to microenvironmental challenges, and the gut mucosa is characterized by low oxygen. Adaptation to low oxygen is mediated by hypoxia-inducible transcription...
7.
Klein K, Kollmann S, Hiesinger A, List J, Kendler J, Klampfl T, et al.
Blood
. 2024 Mar;
143(24):2474-2489.
PMID: 38498036
Patients with T- and natural killer (NK)-cell neoplasms frequently have somatic STAT5B gain-of-function mutations. The most frequent STAT5B mutation is STAT5BN642H, which is known to drive murine T-cell leukemia, although...
8.
Schnoegl D, Hiesinger A, Huntington N, Gotthardt D
Curr Opin Immunol
. 2023 Nov;
85:102397.
PMID: 37931499
The proper functioning of cytotoxic lymphocytes, such as natural killer and CD8+ T cells, is essential for effective cancer-immunity and immunotherapy responses. The differentiation of these cells is controlled by...
9.
Schmidt U, Uluca B, Vokic I, Malik B, Kolbe T, Lassnig C, et al.
PLoS One
. 2023 Sep;
18(9):e0286256.
PMID: 37713409
FAM3C/ILEI is an important factor in epithelial-to-mesenchymal transition (EMT) induction, tumor progression and metastasis. Overexpressed in many cancers, elevated ILEI levels and secretion correlate with poor patient survival. Although ILEI's...
10.