D Z DArgenio
Overview
Explore the profile of D Z DArgenio including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
400
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0
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Recent Articles
1.
The Funnel: a Screening Technique for Identifying Optimal Two-Drug Combination Chemotherapy Regimens
Drusano G, Kim S, Almoslem M, Schmidt S, DArgenio D, Myrick J, et al.
Antimicrob Agents Chemother
. 2020 Nov;
65(2).
PMID: 33199386
The drug discovery effort has generated a substantial number of new/repurposed drugs for therapy for this pathogen. The arrival of these drugs is welcome, but another layer of difficulty has...
2.
Wu L, Jimmerson L, MacBrayne C, Kiser J, DArgenio D
CPT Pharmacometrics Syst Pharmacol
. 2016 Mar;
5(2):65-73.
PMID: 26933517
Ribavirin remains an important component of hepatitis C treatment in certain clinical scenarios, but it causes hemolytic anemia. A quantitative understanding of the ribavirin exposure-anemia relationship is important in dose...
3.
Zamboni W, DArgenio D, Stewart C, MacVittie T, Delauter B, Farese A, et al.
Clin Cancer Res
. 2001 Aug;
7(8):2301-8.
PMID: 11489805
Pharmacodynamic measures of neutropenia, such as absolute neutrophil count at nadir and neutrophil survival fraction, may not reflect the overall time course of neutropenia. We developed a pharmacokinetic-pharmacodynamic model to...
4.
Drusano G, DArgenio D, Preston S, Barone C, Symonds W, Lafon S, et al.
Antimicrob Agents Chemother
. 2000 May;
44(6):1655-9.
PMID: 10817724
The delineation of optimal regimens for combinations of agents is a difficult problem, in part because, to address it, one needs to (i) have effect relationships between the pathogen in...
5.
Snyder S, DArgenio D, Weislow O, Bilello J, Drusano G
Antimicrob Agents Chemother
. 2000 Mar;
44(4):1051-8.
PMID: 10722511
Administration of the combination of indinavir-zidovudine-lamivudine has been demonstrated to cause a large fraction of treated patients to have a decline in human immunodeficiency virus type 1 (HIV-1) copy number...
6.
Drusano G, DArgenio D, Symonds W, Bilello P, McDowell J, Sadler B, et al.
Antimicrob Agents Chemother
. 1998 Sep;
42(9):2153-9.
PMID: 9736527
The use of combinations of anti-human immunodeficiency virus (anti-HIV) agents targeted to different molecular targets will most likely result in increased viral suppression and may also delay or prevent the...
7.
Siebes M, Campbell C, DArgenio D
J Biomech Eng
. 1996 Nov;
118(4):489-97.
PMID: 8950652
The influence of passive vasomotion on the pressure drop-flow (delta P-Q) characteristics of a partially compliant stenosis was studied in an in vitro model of the coronary circulation. Twelve stenosis...
8.
Williams L, Liu A, Chai A, Raubitschek A, Wong J, DArgenio D
Med Phys
. 1995 Oct;
22(10):1619-26.
PMID: 8551986
The question of how to include radioactive decay during biological modeling with first-order differential equations was considered. Modeling may involve either experimental data y(t) or decay-corrected data z(t) [identical to...
9.
DArgenio D, Rodman J
J Pharmacokinet Biopharm
. 1993 Apr;
21(2):223-51.
PMID: 8229682
A stochastic control approach for dose regimen design is developed and applied to the problem of targeting the systemic exposure, defined as the area under the blood concentration-time curve (AUC),...
10.
Kayne L, DArgenio D, Meyer J, Hu M, Jamgotchian N, Lee D
J Clin Invest
. 1993 Mar;
91(3):915-22.
PMID: 8450069
Available information supports the dominance of the proximal intestine in inorganic phosphate (Pi) absorption. However, there is no strategy for analyzing segmental Pi absorption from a spontaneously propelled meal in...