D Stephen Serafin
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Explore the profile of D Stephen Serafin including associated specialties, affiliations and a list of published articles.
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14
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184
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Recent Articles
1.
Balint L, Patel S, Serafin D, Zhang H, Quinn K, Aghajanian A, et al.
bioRxiv
. 2024 Dec;
PMID: 39679907
Background: Ischemic heart disease is a prevalent cause of death and disability worldwide. Recent studies reported a rapid expansion of the cardiac lymphatic network upon ischemic heart injury and proposed...
2.
Serafin D, Harris N, Balint L, Douglas E, Caron K
Nat Commun
. 2024 Sep;
15(1):7734.
PMID: 39232006
The adhesion receptor vascular endothelial (VE)-cadherin transduces an array of signals that modulate crucial lymphatic cell behaviors including permeability and cytoskeletal remodeling. Consequently, VE-cadherin must interact with a multitude of...
3.
Nelson-Maney N, Balint L, Beeson A, Serafin D, Kistner B, Douglas E, et al.
J Clin Invest
. 2024 May;
134(15).
PMID: 38743922
Recently developed antimigraine therapeutics targeting calcitonin gene-related peptide (CGRP) signaling are effective, though their sites of activity remain elusive. Notably, the lymphatic vasculature is responsive to CGRP signaling, but whether...
4.
Tutzauer J, Serafin D, Schmidt T, Olde B, Caron K, Leeb-Lundberg L
Arch Biochem Biophys
. 2024 Jan;
752:109882.
PMID: 38211639
G protein-coupled receptor 30 (GPR30), also named G protein-coupled estrogen receptor (GPER), and the β-adrenergic receptor (β1AR) are G protein-coupled receptors (GPCR) that are implicated in breast cancer progression. Both...
5.
Brozowski J, Timoshchenko R, Serafin D, Allyn B, Koontz J, Rabjohns E, et al.
Stem Cell Res Ther
. 2022 Jan;
13(1):37.
PMID: 35093170
Background: The bone marrow niche supports hematopoietic cell development through intimate contact with multipotent stromal mesenchymal stem cells; however, the intracellular signaling, function, and regulation of such supportive niche cells...
6.
Harris N, Nielsen N, Pawlak J, Aghajanian A, Rangarajan K, Serafin D, et al.
Circ Res
. 2021 Nov;
130(1):5-23.
PMID: 34789016
Background: The adherens protein VE-cadherin (vascular endothelial cadherin) has diverse roles in organ-specific lymphatic vessels. However, its physiological role in cardiac lymphatics and its interaction with lymphangiogenic factors has not...
7.
Kwon H, Mackie D, Bonnavion R, Le Mercier A, Helker C, Son T, et al.
ACS Pharmacol Transl Sci
. 2020 Aug;
3(4):676-689.
PMID: 32832870
The G protein-coupled receptor 182 (GPR182) is an orphan GPCR, the expression of which is enriched in embryonic endothelial cells (ECs). However, the physiological role and molecular mechanism of action...
8.
Serafin D, Harris N, Nielsen N, Mackie D, Caron K
Trends Pharmacol Sci
. 2020 Mar;
41(4):249-265.
PMID: 32115276
Receptor activity-modifying proteins (RAMPs) interact with G-protein-coupled receptors (GPCRs) to modify their functions, imparting significant implications upon their physiological and therapeutic potentials. Resurging interest in identifying RAMP-GPCR interactions has recently...
9.
Antonia R, Castillo J, Herring L, Serafin D, Liu P, Graves L, et al.
Sci Rep
. 2019 Sep;
9(1):13470.
PMID: 31530866
While best known for its role in the innate immune system, the TANK-binding kinase 1 (TBK1) is now known to play a role in modulating cellular growth and autophagy. One...
10.
Agajanian M, Walker M, Axtman A, Ruela-de-Sousa R, Serafin D, Rabinowitz A, et al.
Cell Rep
. 2019 Jan;
26(1):79-93.e8.
PMID: 30605688
β-Catenin-dependent WNT signal transduction governs development, tissue homeostasis, and a vast array of human diseases. Signal propagation through a WNT-Frizzled/LRP receptor complex requires proteins necessary for clathrin-mediated endocytosis (CME). Paradoxically,...