Dawn of a New RAMPage

Overview

Journal Trends Pharmacol Sci

Specialty Pharmacology

Date 2020 Mar 3

PMID 32115276

Citations 19

Authors

D Stephen Serafin

Natalie R Harris

Natalie R Nielsen

Duncan I Mackie

Kathleen M Caron

Affiliations

Soon will be listed here.

Abstract

Receptor activity-modifying proteins (RAMPs) interact with G-protein-coupled receptors (GPCRs) to modify their functions, imparting significant implications upon their physiological and therapeutic potentials. Resurging interest in identifying RAMP-GPCR interactions has recently been fueled by coevolution studies and orthogonal technological screening platforms. These new studies reveal previously unrecognized RAMP-interacting GPCRs, many of which expand beyond Class B GPCRs. The consequences of these interactions on GPCR function and physiology lays the foundation for new molecular therapeutic targets, as evidenced by the recent success of erenumab. Here, we highlight recent papers that uncovered novel RAMP-GPCR interactions, human RAMP-GPCR disease-causing mutations, and RAMP-related human pathologies, paving the way for a new era of RAMP-targeted drug development.

Citing Articles

Tirzepatide, GIP(1-42) and GIP(1-30) display unique signaling profiles at two common GIP receptor variants, E354 and Q354.

Rees T, Buttle B, Tasma Z, Yang S, Harris P, Walker C Front Pharmacol. 2024; 15:1463313.

PMID: 39464637 PMC: 11502443. DOI: 10.3389/fphar.2024.1463313.

G protein-coupled receptors (GPCRs): advances in structures, mechanisms, and drug discovery.

Zhang M, Chen T, Lu X, Lan X, Chen Z, Lu S Signal Transduct Target Ther. 2024; 9(1):88.

PMID: 38594257 PMC: 11004190. DOI: 10.1038/s41392-024-01803-6.

Single transmembrane GPCR modulating proteins: neither single nor simple.

Wang M, Lyu J, Zhang C Protein Cell. 2023; 15(6):395-402.

PMID: 37314044 PMC: 11131010. DOI: 10.1093/procel/pwad035.

Clinical Potential of Adrenomedullin Signaling in the Cardiovascular System.

Balint L, Nelson-Maney N, Tian Y, Serafin S, Caron K Circ Res. 2023; 132(9):1185-1202.

PMID: 37104556 PMC: 10155262. DOI: 10.1161/CIRCRESAHA.123.321673.

Elucidating the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins.

Kotliar I, Lorenzen E, Schwenk J, Hay D, Sakmar T Pharmacol Rev. 2023; 75(1):1-34.

PMID: 36757898 PMC: 9832379. DOI: 10.1124/pharmrev.120.000180.

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