D G Payan
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Explore the profile of D G Payan including associated specialties, affiliations and a list of published articles.
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121
Citations
2185
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Recent Articles
1.
Huang J, Tsvetkov L, Qu K, Daniel-Issakani S, Payan D
Ernst Schering Found Symp Proc
. 2009 Feb;
(1):153-70.
PMID: 19198069
The ubiquitin-proteasome system (UPS) plays an essential role in a wide variety of cell regulatory signaling pathways. The clinical effectiveness of the proteasome inhibitor Velcade in the treatment of several...
2.
Lorens J, Pearsall D, Swift S, Peelle B, Armstrong R, Demo S, et al.
J Biochem Biophys Methods
. 2004 Feb;
58(2):101-10.
PMID: 14980783
As contemporary "genomics" steadily reveals an increasing number of novel gene sequences, the need for efficient methodologies to functionally characterize these genes in vivo increases significantly. Reliable coupling of target...
3.
Gururaja T, Li W, Payan D, Anderson D
J Pept Res
. 2003 Feb;
61(4):163-76.
PMID: 12605602
We used a N-biotinylated peptide analog of the C-terminal domain of the tumor suppressor protein, p21cip1/waf1 to elucidate peptide/protein interacting partners. The C-terminal domain of p21cip1/waf1 protein spanning 141-160 amino...
4.
Lorens J, Sousa C, Bennett M, Molineaux S, Payan D
Curr Opin Biotechnol
. 2002 Feb;
12(6):613-21.
PMID: 11849944
Retrovirally mediated functional genomics enables identification of physiologically relevant cellular therapeutic targets. Unique properties of retroviruses make them ideal tools for the introduction of large and diverse libraries of potential...
5.
Peelle B, Gururaja T, Payan D, Anderson D
J Protein Chem
. 2002 Jan;
20(6):507-19.
PMID: 11760126
Green fluorescent protein (GFP) is useful as an intracellular scaffold for the display of random peptide libraries in yeast. GFPs with a different sequence from Aequorea victoria have recently been...
6.
Holland S, Liao X, Mendenhall M, Zhou X, Pardo J, Chu P, et al.
J Exp Med
. 2001 Nov;
194(9):1263-76.
PMID: 11696592
In an effort to identify novel therapeutic targets for autoimmunity and transplant rejection, we developed and performed a large-scale retroviral-based functional screen to select for proteins that inhibit antigen receptor-mediated...
7.
Peelle B, Lorens J, Li W, Bogenberger J, Payan D, Anderson D
Chem Biol
. 2001 May;
8(5):521-34.
PMID: 11358698
Background: Mammalian cell screens of peptide libraries for changes in cellular phenotype may identify novel functional peptides and their cognate binding partners, and allow identification of signal transduction network members...
8.
Yu P, Huang B, Shen M, Lau C, Chan E, Michel J, et al.
Oncogene
. 2001 Apr;
20(4):484-9.
PMID: 11313979
Proliferating cell nuclear antigen (PCNA) is an essential protein in both DNA replication and DNA damage repair. A novel 15 kD protein, p15(PAF), was identified as a PCNA-associated factor in...
9.
Xu X, Leo C, Jang Y, Chan E, Padilla D, Huang B, et al.
Nat Genet
. 2001 Jan;
27(1):23-9.
PMID: 11137994
We have expressed libraries of peptides in mammalian cells to select for trans-dominant effects on intracellular signaling systems. As an example-and to reveal pharmacologically relevant points in pathways that lead...
10.
Lorens J, Bennett M, Pearsall D, Throndset W, Rossi A, Armstrong R, et al.
Mol Ther
. 2000 Aug;
1(5 Pt 1):438-47.
PMID: 10933965
Stable transduction of genetic material, in combination with sensitive methodologies for in vivo study of cell physiology, provides an opportunity to efficiently evaluate the functions of regulatory proteins. To dissect...