D C Gruenert
Overview
Explore the profile of D C Gruenert including associated specialties, affiliations and a list of published articles.
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90
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2620
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Recent Articles
1.
Jia J, Furlan A, Gonzalez-Hilarion S, Leroy C, Gruenert D, Tulasne D, et al.
Cell Death Differ
. 2015 Mar;
22(11):1754-63.
PMID: 25744026
Nonsense-mediated mRNA decay (NMD) is an mRNA surveillance mechanism that plays integral roles in eliminating mRNAs with premature termination codons to prevent the synthesis of truncated proteins that could be...
2.
de Semir D, Maurisse R, DU F, Xu J, Yang X, Illek B, et al.
Cell Tissue Res
. 2012 Jan;
347(2):357-67.
PMID: 22234514
The prospect of developing large animal models for the study of inherited diseases, such as cystic fibrosis (CF), through somatic cell nuclear transfer (SCNT) has opened up new opportunities for...
3.
Larsen M, Griesenbach U, Goussard S, Gruenert D, Geddes D, Scheule R, et al.
Gene Ther
. 2008 Mar;
15(6):434-42.
PMID: 18317498
Bacteria-mediated gene transfer ('bactofection') has emerged as an alternative approach for genetic vaccination and gene therapy. Here, we assessed bactofection of airway epithelial cells in vitro and in vivo using...
4.
Gruenert D, Willems M, Cassiman J, Frizzell R
J Cyst Fibros
. 2004 Oct;
3 Suppl 2:191-6.
PMID: 15463957
The development of immortalized cell lines has been a significant benefit to the study of human disease, due to limitations in using primary cells and the availability of tissue. The...
5.
Goncz K, Prokopishyn N, Chow B, Davis B, Gruenert D
Gene Ther
. 2002 May;
9(11):691-4.
PMID: 12032689
Gene therapy treatment of disease will be greatly facilitated by the identification of genetic mutations through the Human Genome Project. The specific treatment will ultimately depend on the type of...
6.
Bruscia E, Sangiuolo F, SINIBALDI P, Goncz K, Novelli G, Gruenert D
Gene Ther
. 2002 May;
9(11):683-5.
PMID: 12032687
Cystic fibrosis is the most common inherited disease in the Caucasian population. About 70% of all CF chromosomes carry the DeltaF508 mutation, a 3-bp deletion that results in the loss...
7.
Gruenert D, Novelli G, Dallapiccola B, Colosimo A
Gene Ther
. 2002 May;
9(11):653-7.
PMID: 12032680
The recent surge of DNA sequence information resulting from the efforts of agencies interested in deciphering the human genetic code has facilitated technological developments that have been critical in the...
8.
Goncz K, Colosimo A, Dallapiccola B, Gagne L, Hong K, Novelli G, et al.
Gene Ther
. 2001 Jun;
8(12):961-5.
PMID: 11426337
The development of gene targeting strategies for specific modification of genomic DNA in human somatic cells has provided a potential gene therapy for the treatment of inherited diseases. One approach,...
9.
Wan H, Winton H, Soeller C, Taylor G, Gruenert D, Thompson P, et al.
Clin Exp Allergy
. 2001 Mar;
31(2):279-94.
PMID: 11251630
There have been only a few studies of how allergens cross the airway epithelium to cause allergic sensitization. House dust mite fecal pellets (HDMFP) contain several proteolytic enzymes. Group 1...
10.
Colosimo A, Goncz K, Novelli G, Dallapiccola B, Gruenert D
Mol Ther
. 2001 Mar;
3(2):178-85.
PMID: 11237674
A novel gene targeting strategy, small fragment homologous replacement (SFHR), has been used to correct specific genomic lesions in human epithelial cells. The frequency of targeting was estimated to be...