J E Cleaver
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Explore the profile of J E Cleaver including associated specialties, affiliations and a list of published articles.
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252
Citations
2843
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Recent Articles
1.
Cleaver J, Revet I
Mech Ageing Dev
. 2008 Mar;
129(7-8):492-7.
PMID: 18336867
Cancer, aging, and neurodegeneration are all associated with DNA damage and repair in complex fashions. Aging appears to be a cell and tissue-wide process linked to the insulin-dependent pathway in...
2.
de Feraudy S, Limoli C, Giedzinski E, Karentz D, Marti T, Feeney L, et al.
Oncogene
. 2007 Mar;
26(39):5713-21.
PMID: 17369853
Hydroxyurea reduces DNA replication by nucleotide deprivation, whereas UV damage generates DNA photoproducts that directly block replication fork progression. We show that the low fidelity class Y polymerase Pol eta...
3.
Laposa R, Huang E, Cleaver J
Proc Natl Acad Sci U S A
. 2007 Jan;
104(4):1389-94.
PMID: 17229834
Cockayne syndrome (CS) is a rare recessive childhood-onset neurodegenerative disease, characterized by a deficiency in the DNA repair pathway of transcription-coupled nucleotide excision repair. Mice with a targeted deletion of...
4.
Cleaver J, Hefner E, Laposa R, Karentz D, Marti T
Neuroscience
. 2006 Oct;
145(4):1300-8.
PMID: 17055654
Cockayne syndrome (CS) is a progressive childhood neurodegenerative disorder associated with a DNA repair defect caused by mutations in either of two genes, CSA and CSB. These genes are involved...
5.
Limoli C, Giedzinski E, Cleaver J
Oncogene
. 2005 Mar;
24(23):3708-14.
PMID: 15750628
XP variant (XP-V) cells lack the damage-specific polymerase eta and exhibit prolonged replication arrest after UV irradiation due to impaired bypass of UV photoproducts. To analyse the outcome of the...
6.
Cleaver J
DNA Repair (Amst)
. 2004 Sep;
3(2):183-87.
PMID: 15344228
Most forms of the human hereditary disease xeroderma pigmentation (XP) are due to a defect in nucleotide excision repair of DNA damage in skin cells associated with exposure to sunlight....
7.
Cleaver J, Collins C, Ellis J, Volik S
Genomics
. 2003 Oct;
82(5):561-70.
PMID: 14559213
POLH and POLI are paralogs encoding low-fidelity, class Y, DNA polymerases involved in replication of damaged DNA in the human disease xeroderma pigmentosum variant. Analysis of genomic regions for human...
8.
Schneider T, Barland C, Alex A, Mancianti M, Lu Y, Cleaver J, et al.
Proc Natl Acad Sci U S A
. 2003 Sep;
100(20):11412-7.
PMID: 13679571
Epidermal stem cells play a central role in tissue homeostasis, wound repair, tumor initiation, and gene therapy. A major impediment to the purification and molecular characterization of epidermal stem cells...
9.
Cleaver J, Laposa R, Limoli C
Cell Cycle
. 2003 Jul;
2(4):310-5.
PMID: 12851481
We describe here a model for sequential recruitment of various enzymatic systems that maintain DNA replication fidelity in cells with damaged bases, especially those formed by ultraviolet (UV) irradiation. Systems...
10.
Cleaver J, Bartholomew J, Char D, Crowley E, Feeney L, Limoli C
DNA Repair (Amst)
. 2003 Jan;
1(1):41-57.
PMID: 12509296
Xeroderma pigmentosum variant (XPV) cells lack the damage-specific polymerase eta and undergo a protracted arrest at the S phase checkpoint(s) following UV damage. The S phase checkpoints encompass several qualitatively...