D B Northrop
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Explore the profile of D B Northrop including associated specialties, affiliations and a list of published articles.
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55
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Recent Articles
1.
Northrop D
Acc Chem Res
. 2001 Oct;
34(10):790-7.
PMID: 11601963
Seven proton transfers in five steps participate in a catalytic turnover of an aspartic protease. The Rosetta Stone for elucidating their role is a low-barrier hydrogen bond that holds the...
2.
Northrop D
Methods
. 2001 Jun;
24(2):117-24.
PMID: 11384187
There have been few recent additions to the technical methods employed in the study of isotope effects, notable exceptions being the use of high pressure as an experimental variable and...
3.
Quirk D, Northrop D
Biochemistry
. 2001 Feb;
40(3):847-51.
PMID: 11170403
High pressure causes biphasic effects on the oxidation of formate by yeast formate dehydrogenase as expressed on the kinetic parameter V/K, which measures substrate capture. Moderate pressure increases capture by...
4.
Northrop D, Cho Y
Biophys J
. 2000 Sep;
79(3):1621-8.
PMID: 10969022
The effect of pressure on the capture of a substrate alcohol by yeast alcohol dehydrogenase is biphasic. Solvent isotope effects accompany both phases and are expressed differently at different pressures....
5.
Northrop D, Cho Y
Biochemistry
. 2000 Mar;
39(9):2406-12.
PMID: 10694410
Moderate pressure accelerates hydride transfer catalyzed by yeast alcohol dehydrogenase, indicative of a large negative volume of activation [Cho and Northrop (1999) Biochemistry 38, 7470-7475]. A comparison of the effects...
6.
7.
Cho Y, Northrop D
Biochemistry
. 1999 Jun;
38(23):7470-5.
PMID: 10360944
High pressure causes biphasic effects on the oxidation of benzyl alcohol by yeast alcohol dehydrogenase as expressed in the kinetic parameter V/K which measures substrate capture. Moderate pressure increases the...
8.
Northrop D
Adv Enzymol Relat Areas Mol Biol
. 1999 Apr;
73:25-55, ix.
PMID: 10218105
Despite certain limitations, investigators continue to gainfully employ concepts rooted in steady-state kinetics in efforts to draw mechanistically relevant inferences about enzyme catalysis. By reconsidering steady-state enzyme kinetic behavior, this...
9.
Cho Y, Northrop D
J Biol Chem
. 1998 Sep;
273(38):24305-8.
PMID: 9733715
Porcine pepsin proteolysis of the hexapeptide Leu-Ser-p-nitro-Phe-Nle-Ala-Leu-OMe (where OMe = methoxy and Nle = norleucine) in the presence of dipeptide Leu-Leu synthesizes a new hexapeptide Leu-Ser-p-nitro-Phe-Leu-Leu. Contrary to transpeptidation kinetics...
10.
Northrop D, Simpson F
Arch Biochem Biophys
. 1998 May;
352(2):288-92.
PMID: 9587418
Induced transport of 13CO2 to H13CO3- by bovine carbonic anhydrase II in the presence of excess H12CO3- at pH 6.35 causes a temporary decrease in the concentration of 13CO2 from...