C J Newton
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Explore the profile of C J Newton including associated specialties, affiliations and a list of published articles.
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51
Citations
464
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Recent Articles
1.
Xu S, Zhong W, Watson N, Dickerson E, Wake J, Lindow S, et al.
J Thromb Haemost
. 2008 Jan;
6(4):692-700.
PMID: 18221360
Background: 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have been widely used in clinical practise and their efficacy in reducing cardiovascular risk has been well described. Objectives: To investigate the effect...
2.
Newton C, Ran G, Xie Y, Bilko D, Burgoyne C, Adams I, et al.
J Endocrinol
. 2005 Oct;
187(1):167.
PMID: 16214952
No abstract available.
3.
Newton C, Xie Y, Burgoyne C, Adams I, Atkin S, Abidia A, et al.
Cardiovasc Surg
. 2003 Jan;
11(1):52-60.
PMID: 12543573
Statins block de novo synthesis of cholesterol by inhibiting the enzyme, HMG CoA reductase. The product of this reaction, mevalonic acid, is also a precursor of isoprenoids, molecules required for...
4.
Newton C, Ran G, Xie Y, Bilko D, Burgoyne C, Adams I, et al.
J Endocrinol
. 2002 Jul;
174(1):7-16.
PMID: 12098658
Statins block de novo synthesis of cholesterol by inhibiting the enzyme, HMG CoA reductase. The product of this reaction, mevalonic acid, is also a precursor of isoprenoids, molecules required for...
5.
Wilson D, Dailey R, Griffeth M, Newton C
Ophthalmic Plast Reconstr Surg
. 2001 Jul;
17(4):300-3.
PMID: 11476182
Purpose: To report the clinicopathologic features of a 17-year-old patient with primary Ewing sarcoma of the orbit. Methods: The patient was evaluated clinically before surgery with computed tomography scans of...
6.
Newton C, Bilko D, Pappa S, Atkin S
J Endocrinol
. 2001 Apr;
169(2):249-61.
PMID: 11312142
The oestrogen receptor is fundamental to the growth and survival of the rat pituitary tumour cell line, GH(3). Our previous studies have shown that antioestrogens such as RU 58668 and...
7.
Speirs V, Kerin M, Walton D, Newton C, Desai S, Atkin S
Br J Cancer
. 2001 Feb;
82(7):1312-6.
PMID: 10755407
Interleukin 6 (IL-6) is secreted by breast tumours and shows synergistic activity with 17beta-oestradiol (E2), leading to increases in reductive 17beta-hydroxysteroid dehydrogenase activity in breast cancer epithelial cells. However, the...
8.
Newton C, Eycott K, Green V, Atkin S
J Steroid Biochem Mol Biol
. 2000 May;
73(1-2):29-38.
PMID: 10822022
Cell survival is dependent on both external and internally generated signalling processes and current strategies for medical intervention in neoplastic disease are directed towards signal transduction blockade. Redundancy in signalling...
9.
Speirs V, Kerin M, Newton C, Walton D, Green A, Desai S, et al.
Int J Oncol
. 1999 Nov;
15(6):1251-4.
PMID: 10568836
Estrogen is mitogenic in breast cancer where IL-1beta also fulfils a role. The aim of this study was to determine any relationship between IL-1beta and ERalpha in breast cancer. By...
10.
Newton C, Drummond N, Burgoyne C, Speirs V, Stalla G, Atkin S
J Endocrinol
. 1999 May;
161(2):199-210.
PMID: 10320817
Reactive oxygen species (ROS) play a fundamental role in both apoptotic and necrotic cell death. Their importance is highlighted by studies showing that they mediate cell death in response to...