D A McClain
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Explore the profile of D A McClain including associated specialties, affiliations and a list of published articles.
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57
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1277
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Recent Articles
1.
Addison O, Drummond M, LaStayo P, Dibble L, Wende A, McClain D, et al.
J Nutr Health Aging
. 2014 Jun;
18(5):532-8.
PMID: 24886741
Objectives: Intramuscular adipose tissue (IMAT) is recognized as a negative predictor of both muscle and mobility function in older adults, however the mechanism by which IMAT may negatively influence muscle...
2.
Marcus R, Addison O, LaStayo P, Hungerford R, Wende A, Hoffman J, et al.
J Endocrinol Invest
. 2012 Apr;
36(2):111-7.
PMID: 22522495
Background: Aging is associated with a decline in skeletal muscle size.Muscle is critical both for mobility and glucose disposal. While resistance exercise (RE) increases muscle mass and function in the...
3.
Abraham D, Rogers J, Gault P, Kushner J, McClain D
Diabetologia
. 2006 Oct;
49(11):2546-51.
PMID: 17019598
Aims/hypothesis: We recently demonstrated that humans with hereditary haemochromatosis have decreased insulin secretory capacity with a compensatory increase in insulin sensitivity. We therefore determined how these measures change after correction...
4.
McClain D, Abraham D, Rogers J, Brady R, Gault P, Ajioka R, et al.
Diabetologia
. 2006 Mar;
49(7):1661-9.
PMID: 16538487
Aims/hypothesis: The prevalence and mechanisms of diabetes in hereditary haemochromatosis are not known. We therefore measured glucose tolerance, insulin secretory capacity and insulin sensitivity in adults with haemochromatosis. Subjects And...
5.
Veerababu G, Tang J, Hoffman R, Daniels M, Hebert Jr L, Crook E, et al.
Diabetes
. 2000 Dec;
49(12):2070-8.
PMID: 11118009
To examine the effect of increased hexosamine flux in liver, the rate-limiting enzyme in hexosamine biosynthesis (glutamine:fructose-6-phosphate amidotransferase [GFA]) was overexpressed in transgenic mice using the PEPCK promoter. Liver from...
6.
Considine R, Cooksey R, Williams L, Fawcett R, Zhang P, Ambrosius W, et al.
J Clin Endocrinol Metab
. 2000 Nov;
85(10):3551-6.
PMID: 11061500
The hexosamine biosynthetic pathway has recently been proposed as a mechanism through which cells "sense" nutrient flux to regulate leptin release. This study was undertaken to examine the regulation of...
7.
Tang J, Neidigh J, Cooksey R, McClain D
Diabetes
. 2000 Sep;
49(9):1492-9.
PMID: 10969833
Hexosamines have been shown to mediate effects of hyperglycemia and so-called "glucose toxicity" in insulin-sensitive tissues. To determine the effects of hexosamines on insulin synthesis and secretion, transgenic mice were...
8.
McClain D, Alexander T, Cooksey R, Considine R
Endocrinology
. 2000 Jun;
141(6):1999-2002.
PMID: 10830282
Hexosamine flux has been shown to mediate aspects of nutrient sensing in insulin sensitive tissues and has been hypothesized to represent a satiety signal that results in shunting of fuel...
9.
Daniels M, McClain D, Crook E
Am J Med Sci
. 2000 Apr;
319(3):138-42.
PMID: 10746823
Background: The hexosamine biosynthesis pathway (HBP) is hypothesized to mediate many of the adverse effects of hyperglycemia. We have shown previously that increased flux through this pathway leads to induction...
10.
SIMMONS S, Daniels M, Huddleston E, Hebert Jr L, McClain D, Crook E
Res Commun Mol Pathol Pharmacol
. 1999 Dec;
104(1):63-72.
PMID: 10604279
The biosynthetic pathway for hexosamine mediates some of the adverse effects of high glucose. The rate limiting enzyme in this pathway is glutamine:fructose-6-phosphate amidotransferase (GFA). Using HPLC, the regulation of...