Cristina Cavinato
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Explore the profile of Cristina Cavinato including associated specialties, affiliations and a list of published articles.
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28
Citations
152
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Recent Articles
11.
Chen W, Van Beusecum J, Xiao L, Patrick D, Ao M, Zhao S, et al.
Am J Physiol Heart Circ Physiol
. 2022 Sep;
323(5):H917-H933.
PMID: 36083796
We have shown that excessive endothelial cell stretch causes release of growth arrest-specific 6 (GAS6), which activates the tyrosine kinase receptor Axl on monocytes and promotes immune activation and inflammation....
12.
Chen M, Hu R, Cavinato C, Zhuang Z, Zhang J, Yun S, et al.
Diabetes
. 2022 Jun;
71(9):2020-2033.
PMID: 35771994
Vascular complications are a major cause of illness and death in patients with type 1 diabetes (T1D). Diabetic vascular basement membranes are enriched in fibronectin (FN), an extracellular matrix protein...
13.
Linka K, Cavinato C, Humphrey J, Cyron C
Acta Biomater
. 2022 Jun;
147:63-72.
PMID: 35643194
Microstructural features and mechanical properties are closely related in all soft biological tissues. Both yet exhibit considerable inter-individual differences and are affected by factors such as aging and disease and...
14.
Yin M, Ban E, Rego B, Zhang E, Cavinato C, Humphrey J, et al.
J R Soc Interface
. 2022 Feb;
19(187):20210670.
PMID: 35135299
Aortic dissection progresses mainly via delamination of the medial layer of the wall. Notwithstanding the complexity of this process, insight has been gleaned by studying and the progression of dissection...
15.
Ban E, Cavinato C, Humphrey J
Ann Biomed Eng
. 2022 Jan;
50(2):183-194.
PMID: 35044571
Computational models of aortic dissection can examine mechanisms by which this potentially lethal condition develops and propagates. We present results from phase-field finite element simulations that are motivated by a...
16.
Cavinato C, Chen M, Weiss D, Ruiz-Rodriguez M, Schwartz M, Humphrey J
Front Cardiovasc Med
. 2022 Jan;
8:800730.
PMID: 34977201
Medial deterioration leading to thoracic aortic aneurysms arises from multiple causes, chief among them mutations to the gene that encodes fibrillin-1 and leads to Marfan syndrome. Fibrillin-1 microfibrils associate with...
17.
Manning E, Ramachandra A, Schupp J, Cavinato C, Raredon M, Barnthaler T, et al.
Front Physiol
. 2021 Oct;
12:726253.
PMID: 34594238
Hypoxia adversely affects the pulmonary circulation of mammals, including vasoconstriction leading to elevated pulmonary arterial pressures. The clinical importance of changes in the structure and function of the large, elastic...
18.
Cavinato C, Murtada S, Rojas A, Humphrey J
Mech Ageing Dev
. 2021 Mar;
196:111471.
PMID: 33741396
The evolving microstructure and mechanical properties that promote homeostasis in the aorta are fundamental to age-specific adaptations and disease progression. We combine ex vivo multiphoton microscopy and biaxial biomechanical phenotyping...
19.
Ban E, Cavinato C, Humphrey J
Biomech Model Mechanobiol
. 2021 Jan;
20(3):895-907.
PMID: 33464476
Aortic dissections progress, in part, by delamination of the wall. Previous experiments on cut-open segments of aorta demonstrated that fluid injected within the wall delaminates the aorta in two distinct...
20.
Weiss D, Cavinato C, Gray A, Ramachandra A, Avril S, Humphrey J, et al.
Sci Adv
. 2020 Dec;
6(49).
PMID: 33277255
Arterial tortuosity manifests in many conditions, including hypertension, genetic mutations predisposing to thoracic aortopathy, and vascular aging. Despite evidence that tortuosity disrupts efficient blood flow and that it may be...