Craig Freeman
Overview
Explore the profile of Craig Freeman including associated specialties, affiliations and a list of published articles.
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Articles
36
Citations
931
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0
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Recent Articles
1.
Meara C, Coupland L, Kordbacheh F, Quah B, Chang C, Simon Davis D, et al.
Nat Commun
. 2020 Dec;
11(1):6408.
PMID: 33328478
Extracellular histones in neutrophil extracellular traps (NETs) or in chromatin from injured tissues are highly pathological, particularly when liberated by DNases. We report the development of small polyanions (SPAs) (~0.9-1.4 ...
2.
Simeonovic C, Popp S, Brown D, Li F, Lafferty A, Freeman C, et al.
Adv Exp Med Biol
. 2020 Apr;
1221:607-630.
PMID: 32274728
Type 1 diabetes (T1D) results from autoimmune destruction of insulin-producing beta cells in pancreatic islets. The degradation of the glycosaminoglycan heparan sulfate (HS) by the endo-β-D-glycosidase heparanase plays a critical...
3.
Simeonovic C, Popp S, Starrs L, Brown D, Ziolkowski A, Ludwig B, et al.
PLoS One
. 2018 Feb;
13(2):e0191360.
PMID: 29415062
Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing beta cells in pancreatic islets are progressively destroyed. Clinical trials of immunotherapies in recently diagnosed T1D patients have only...
4.
Boyle M, Skidmore M, Dickerman B, Cooper L, Devlin A, Yates E, et al.
Antimicrob Agents Chemother
. 2017 Sep;
61(11).
PMID: 28893781
Despite recent successful control efforts, malaria remains a leading global health burden. Alarmingly, resistance to current antimalarials is increasing and the development of new drug families is needed to maintain...
5.
S-maltoheptaose targets syndecan-bound effectors to reduce smoking-related neutrophilic inflammation
Lam D, Chan S, Mak J, Freeman C, Ip M, Shum D
Sci Rep
. 2015 Aug;
5:12945.
PMID: 26256047
Cigarette smoke induces injury and neutrophilic inflammation in the airways of smokers. The stability and activity of inflammatory effectors, IL8 and neutrophil elastase (NE), can be prolonged by binding to...
6.
Troeberg L, Lazenbatt C, Anower-E-Khuda M, Freeman C, Federov O, Habuchi H, et al.
Chem Biol
. 2014 Sep;
21(10):1300-1309.
PMID: 25176127
Tissue inhibitor of metalloproteinase 3 (TIMP-3) is an important regulator of extracellular matrix (ECM) turnover. TIMP-3 binds to sulfated ECM glycosaminoglycans or is endocytosed by cells via low-density lipoprotein receptor-related...
7.
Simeonovic C, Ziolkowski A, Wu Z, Choong F, Freeman C, Parish C
Front Immunol
. 2014 Jan;
4:471.
PMID: 24421779
Heparanase (Hpse) is the only known mammalian endo-β-d-glucuronidase that degrades the glycosaminoglycan heparan sulfate (HS), found attached to the core proteins of heparan sulfate proteoglycans (HSPGs). Hpse plays a homeostatic...
8.
Cui H, Freeman C, Jacobson G, Small D
IUBMB Life
. 2013 Jan;
65(2):108-20.
PMID: 23297096
Proteoglycans (PGs) are major components of the cell surface and extracellular matrix and play critical roles in development and maintenance of the central nervous system (CNS). PGs are a family...
9.
Hu J, Song X, He Y, Freeman C, Parish C, Yuan L, et al.
Invest Ophthalmol Vis Sci
. 2012 Sep;
53(11):6810-7.
PMID: 22956610
Purpose: Heparanase and VEGF are related closely to angiogenesis in cancer. The purpose of our study was to evaluate the expression and correlation of heparanase and VEGF in hypoxia-induced retinal...
10.
Cui H, Hung A, Freeman C, Narkowicz C, Jacobson G, Small D
J Neurochem
. 2012 Aug;
123(3):447-57.
PMID: 22909067
Alzheimer's disease is associated with abnormal accumulation of Aβ, which is produced from the β-amyloid precursor protein (APP) by the β-site APP-cleaving enzyme (BACE1) and γ-secretase. Our previous studies showed...