Craig A Simmons
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Explore the profile of Craig A Simmons including associated specialties, affiliations and a list of published articles.
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146
Citations
3872
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Recent Articles
1.
Takeuchi L, Kalia L, Simmons C
Neurobiol Dis
. 2025 Mar;
:106864.
PMID: 40089165
Alzheimer's Disease (AD) remains an overwhelming epidemiologic and economic burden on our healthcare systems, affecting an estimate of 11 % of individuals aged 65 years and older. Increasing evidence of...
2.
Tang M, Zhou Y, Blaser M, Steinman D, Simmons C
Ultrasound Med Biol
. 2025 Feb;
PMID: 39971688
Objective: Abnormal hemodynamics is thought to play an essential role in the development of cardiovascular diseases. Mouse models are widely used for elucidating the underlying mechanisms; however, their small size...
3.
Lino M, Persson H, Paknahad M, Ugodnikov A, Farhang Ghahremani M, Takeuchi L, et al.
Lab Chip
. 2025 Feb;
25(6):1489-1501.
PMID: 39925127
Biological barriers formed by the endothelium and epithelium regulate nutrient exchange, disease development, and drug delivery. Organ-on-chip (OOC) systems effectively model these barriers by incorporating key biophysical cues like microscale...
4.
Adao D, Ching C, Fish J, Simmons C, Billia F
Clin Sci (Lond)
. 2024 Nov;
138(21):1395-1419.
PMID: 39492693
To maintain homeostasis in the heart, endothelial cells and cardiomyocytes engage in dynamic cross-talk through paracrine signals that regulate both cardiac development and function. Here, we review the paracrine signals...
5.
Wu N, Quevedo R, Nurse M, Hezaveh K, Liu H, Sun F, et al.
Biomaterials
. 2024 Oct;
314:122879.
PMID: 39395244
Cancer-associated fibroblasts (CAFs) play a pivotal role in cancer progression, including mediating tumour cell invasion via their pro-invasive secretory profile and ability to remodel the extracellular matrix (ECM). Given that...
6.
Zhang X, Zhao G, Ma T, Simmons C, Santerre J
Acta Biomater
. 2024 Oct;
189:1-24.
PMID: 39374681
Myocardial infarction (MI), which causes irreversible myocardium necrosis, affects 0.25 billion people globally and has become one of the most significant epidemics of our time. Over the past few years,...
7.
Characterization of pediatric porcine pulmonary valves as a model for tissue engineered heart valves
Parvin Nejad S, Mirani B, Mirzaei Z, Simmons C
Acta Biomater
. 2024 Sep;
188:242-252.
PMID: 39233254
Heart valve tissue engineering holds the potential to transform the surgical management of congenital heart defects affecting the pediatric pulmonary valve (PV) by offering a viable valve replacement. While aiming...
8.
Villalobos Lizardi J, Baranger J, Nguyen M, Asnacios A, Malik A, Lumens J, et al.
Nat Cardiovasc Res
. 2024 Aug;
1(1):8-22.
PMID: 39196108
Myocardial stiffness is an intrinsic property of the myocardium that influences both diastolic and systolic cardiac function. Myocardial stiffness represents the resistance of this tissue to being deformed and depends...
9.
Ugodnikov A, Chebotarev O, Persson H, Simmons C
ACS Biomater Sci Eng
. 2024 Jun;
10(8):5327-5335.
PMID: 38943620
Measurement of endothelial and epithelial barrier integrity is important for a variety of in vitro models, including Transwell assays, cocultures, and organ-on-chip platforms. Barrier resistance is typically measured by trans-endothelial...
10.
Guruji V, Zhou Y, Tang M, Mirzaei Z, Ding Y, Elbatarny M, et al.
Am J Physiol Heart Circ Physiol
. 2024 May;
327(1):H56-H66.
PMID: 38758128
Mouse models of congenital aortic valve malformations are useful for studying disease pathobiology, but most models have incomplete penetrance [e.g., ∼2 to 77% prevalence of bicuspid aortic valves (BAVs) across...