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Craig A Simmons

Explore the profile of Craig A Simmons including associated specialties, affiliations and a list of published articles. Areas
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Articles 146
Citations 3872
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Recent Articles
11.
Ugodnikov A, Persson H, Simmons C
Lab Chip . 2024 May; 24(13):3199-3225. PMID: 38689569
Biological barriers such as the blood-brain barrier, skin, and intestinal mucosal barrier play key roles in homeostasis, disease physiology, and drug delivery - as such, it is important to create...
12.
Kinnear C, Said A, Meng G, Zhao Y, Wang E, Rafatian N, et al.
Cell Rep Med . 2024 Apr; 5(5):101520. PMID: 38642550
Pathogenic variants in MYH7 and MYBPC3 account for the majority of hypertrophic cardiomyopathy (HCM). Targeted drugs like myosin ATPase inhibitors have not been evaluated in children. We generate patient and...
13.
Mohan M, Latifi N, Flick R, Simmons C, Young E
ACS Appl Mater Interfaces . 2024 Apr; PMID: 38606850
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense fibrotic stroma that contributes to aggressive tumor biology and therapeutic resistance. Current in vitro PDAC models lack sufficient optical and physical...
14.
Chebotarev O, Ugodnikov A, Simmons C
ACS Appl Bio Mater . 2024 Mar; 7(3):2000-2011. PMID: 38447196
Cell culture models of endothelial and epithelial barriers typically use porous membrane inserts (e.g., Transwell inserts) as a permeable substrate on which barrier cells are grown, often in coculture with...
15.
Chung J, Eliathamby D, Seo H, Fan C, Islam R, Deol K, et al.
JTCVS Open . 2024 Jan; 16:38-47. PMID: 38204645
Background: Although aneurysms of the ascending aorta and the aortic root are treated similarly in clinical guidelines, how biomechanical properties differ between these 2 segments of aorta is poorly defined....
16.
Strohm E, Callaghan N, Ding Y, Latifi N, Rafatian N, Funakoshi S, et al.
ACS Nano . 2023 Dec; 18(1):314-327. PMID: 38147684
Cell-based models that mimic in vivo heart physiology are poised to make significant advances in cardiac disease modeling and drug discovery. In these systems, cardiomyocyte (CM) contractility is an important...
17.
Siqueira N, Chung S, Shrestha S, Zhong A, Caruso L, Mirani B, et al.
Biomacromolecules . 2023 Jun; 24(7):3149-3158. PMID: 37344353
In a healthy heart, cells naturally secrete C-type natriuretic peptide (CNP), a cytokine that protects against myofibroblast differentiation of cardiac fibroblasts and extracellular matrix deposition leading to fibrosis. CNP availability...
18.
Parvin Nejad S, Lecce M, Mirani B, Machado Siqueira N, Mirzaei Z, Santerre J, et al.
Stem Cell Res Ther . 2023 Apr; 14(1):96. PMID: 37076906
Background: Constructs currently used to repair or replace congenitally diseased pediatric heart valves lack a viable cell population capable of functional adaptation in situ, necessitating repeated surgical intervention. Heart valve...
19.
Eliathamby D, Keshishi M, Ouzounian M, Forbes T, Tan K, Simmons C, et al.
JTCVS Open . 2023 Apr; 13:32-44. PMID: 37063150
Objective: The objective of this study was to evaluate the relationship between ascending aortic geometry and biomechanical properties. Methods: Preoperative computed tomography scans from ascending aortic aneurysm patients were analyzed...
20.
Sebastian J, Strohm E, Baranger J, Villemain O, Kolios M, Simmons C
Biomaterials . 2023 Feb; 296:122054. PMID: 36842239
Quantitative assessment of the structural, functional, and mechanical properties of engineered tissues and biomaterials is fundamental to their development for regenerative medicine applications. Ultrasound (US) imaging is a non-invasive, non-destructive,...