Christoph Rademacher
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Explore the profile of Christoph Rademacher including associated specialties, affiliations and a list of published articles.
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82
Citations
1229
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Recent Articles
1.
Rahhal N, Rentzsch M, Seiser S, Freystatter C, Elbe-Burger A, Rademacher C
Nanoscale
. 2025 Jan;
17(7):4038-4046.
PMID: 39775685
Targeted delivery has emerged as a critical strategy in the development of novel therapeutics. The advancement of nanomedicine hinges on the safe and precise cell-specific delivery of protein-based therapeutics to...
2.
Lefebre J, Falk T, Ning Y, Rademacher C
Chemistry
. 2024 Mar;
30(30):e202400660.
PMID: 38527187
C-type lectins are a large superfamily of proteins involved in a multitude of biological processes. In particular, their involvement in immunity and homeostasis has rendered them attractive targets for diverse...
3.
Leusmann S, Menova P, Shanin E, Titz A, Rademacher C
Chem Soc Rev
. 2023 May;
52(11):3663-3740.
PMID: 37232696
Carbohydrates are essential mediators of many processes in health and disease. They regulate self-/non-self- discrimination, are key elements of cellular communication, cancer, infection and inflammation, and determine protein folding, function...
4.
Fuchsberger F, Kim D, Baranova N, Vrban H, Kagelmacher M, Wawrzinek R, et al.
Elife
. 2023 Feb;
12.
PMID: 36803584
Glycan-binding proteins, so-called lectins, are exposed on mammalian cell surfaces and decipher the information encoded within glycans translating it into biochemical signal transduction pathways in the cell. These glycan-lectin communication...
5.
Shanina E, Kuhaudomlarp S, Siebs E, Fuchsberger F, Denis M, Gomes P, et al.
Commun Chem
. 2023 Jan;
5(1):64.
PMID: 36697615
Carbohydrate-protein interactions are key for cell-cell and host-pathogen recognition and thus, emerged as viable therapeutic targets. However, their hydrophilic nature poses major limitations to the conventional development of drug-like inhibitors....
6.
Zhang H, Modenutti C, Nekkanti Y, Denis M, Bermejo I, Lefebre J, et al.
ACS Chem Biol
. 2022 Sep;
17(10):2728-2733.
PMID: 36153965
Langerin is a mammalian C-type lectin expressed on Langerhans cells in the skin. As an innate immune cell receptor, Langerin is involved in coordinating innate and adaptive immune responses against...
7.
Zhang H, Danek O, Makarov D, Radl S, Kim D, Ledvinka J, et al.
ACS Med Chem Lett
. 2022 Jun;
13(6):935-942.
PMID: 35707152
DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin) is a pattern recognition receptor expressed on immune cells and involved in the recognition of carbohydrate signatures present on various pathogens, including HIV,...
8.
Stoitzner P, Romani N, Rademacher C, Probst H, Mahnke K
Eur J Immunol
. 2022 May;
52(12):1909-1924.
PMID: 35598160
The hallmark of DCs is their potent and outstanding capacity to activate naive resting T cells. As such, DCs are the sentinels of the immune system and instrumental for the...
9.
Freichel T, Laaf D, Hoffmann M, Konietzny P, Heine V, Wawrzinek R, et al.
RSC Adv
. 2022 May;
9(41):23484-23497.
PMID: 35530592
In this work, we present a bottom-up approach for the synthesis of lactose-functionalized glycomacromolecules and glycofunctionalized liposomes and apply these compounds to investigate their effects of multivalent presentation on binding...
10.
Ghosh C, Priegue P, Leelayuwapan H, Fuchsberger F, Rademacher C, Seeberger P
ACS Appl Bio Mater
. 2022 Apr;
5(5):2185-2192.
PMID: 35435657
Nanoparticles that modulate innate immunity can act as vaccine adjuvants and antigen carriers and are promising alternatives to conventional anticancer therapy. Nanoparticles might, upon contact with serum, activate the complement...