Corneliu N Craciunescu
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Explore the profile of Corneliu N Craciunescu including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Niculescu M, Lupu D, Craciunescu C
FASEB J
. 2012 Sep;
27(1):350-8.
PMID: 22997227
Previous studies indicated that the intake of α-linolenic acid (ALA) can alter the concentration of both ω-6 and ω-3 fatty acids in both mother and offspring, with consequences on postnatal...
2.
Niculescu M, Lupu D, Craciunescu C
Int J Dev Neurosci
. 2011 Oct;
29(8):795-802.
PMID: 21964326
The availability of ω-3 polyunsaturated fatty acids is essential for perinatal brain development. While the roles of docosahexaenoic acid (the most abundant ω-3 species) were extensively described, less is known...
3.
Mehedint M, Craciunescu C, Zeisel S
Proc Natl Acad Sci U S A
. 2010 Jul;
107(29):12834-9.
PMID: 20624989
We examined whether maternal dietary choline modulates angiogenesis in fetal brain. Pregnant C57BL/6 mice were fed either a choline-deficient (CD), control (CT), or choline-supplemented diet (CS) from days 12 to...
4.
Craciunescu C, Johnson A, Zeisel S
J Nutr
. 2010 Apr;
140(6):1162-6.
PMID: 20392884
In mice, maternal dietary folate, a cofactor in 1-carbon metabolism, modulates neurogenesis and apoptosis in the fetal brain. Similarly, maternal dietary choline, an important methyl-donor, also influences these processes. Choline...
5.
Johnson A, Craciunescu C, Guo Z, Teng Y, Thresher R, Blusztajn J, et al.
FASEB J
. 2010 Apr;
24(8):2752-61.
PMID: 20371614
Choline dehydrogenase (CHDH) catalyzes the conversion of choline to betaine, an important methyl donor and organic osmolyte. We have previously identified single nucleotide polymorphisms (SNPs) in the human CHDH gene...
6.
da Costa K, Rai K, Craciunescu C, Parikh K, Mehedint M, Sanders L, et al.
J Biol Chem
. 2009 Nov;
285(2):1008-15.
PMID: 19889625
The development of fetal brain is influenced by nutrients such as docosahexaenoic acid (DHA, 22:6) and choline. Phosphatidylethanolamine-N-methyltransferase (PEMT) catalyzes the biosynthesis of phosphatidylcholine from phosphatidylethanolamine enriched in DHA and...
7.
Mehedint M, Niculescu M, Craciunescu C, Zeisel S
FASEB J
. 2009 Sep;
24(1):184-95.
PMID: 19752176
Maternal choline availability is essential for fetal neurogenesis. Choline deprivation (CD) causes hypomethylation of specific CpG islands in genes controlling cell cycling in fetal hippocampus. We now report that, in...
8.
Craciunescu C, Niculescu M, Guo Z, Johnson A, Fischer L, Zeisel S
Toxicol Sci
. 2008 Oct;
107(1):220-6.
PMID: 18948303
Diethanolamine (DEA) is a common ingredient of personal care products. Dermal administration of DEA diminishes hepatic stores of the essential nutrient choline and alters brain development. We previously reported that...
9.
Craciunescu C, Wu R, Zeisel S
FASEB J
. 2006 Jul;
20(10):1635-40.
PMID: 16873886
Diethanolamine (DEA) is present in many consumer products such as shampoo. Dermal administration of DEA diminishes hepatic stores of the essential nutrient choline, and we previously reported that dietary choline...
10.
da Costa K, Niculescu M, Craciunescu C, Fischer L, Zeisel S
Am J Clin Nutr
. 2006 Jul;
84(1):88-94.
PMID: 16825685
Background: Whereas deficiency of the essential nutrient choline is associated with DNA damage and apoptosis in cell and rodent models, it has not been shown in humans. Objective: The objective...