Mihai G Mehedint
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Explore the profile of Mihai G Mehedint including associated specialties, affiliations and a list of published articles.
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5
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321
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Recent Articles
1.
Mehedint M, Zeisel S
Curr Opin Clin Nutr Metab Care
. 2013 Mar;
16(3):339-45.
PMID: 23493015
Purpose Of Review: Humans eating diets low in choline develop fatty liver and liver damage. Rodents fed choline-methionine-deficient diets not only develop fatty liver, but also progress to develop fibrosis...
2.
Teng Y, Mehedint M, Garrow T, Zeisel S
J Biol Chem
. 2011 Sep;
286(42):36258-67.
PMID: 21878621
Betaine-homocysteine S-methyltransferase (BHMT) uses betaine to catalyze the conversion of homocysteine (Hcy) to methionine. There are common genetic polymorphisms in the BHMT gene in humans that can alter its enzymatic...
3.
Mehedint M, Craciunescu C, Zeisel S
Proc Natl Acad Sci U S A
. 2010 Jul;
107(29):12834-9.
PMID: 20624989
We examined whether maternal dietary choline modulates angiogenesis in fetal brain. Pregnant C57BL/6 mice were fed either a choline-deficient (CD), control (CT), or choline-supplemented diet (CS) from days 12 to...
4.
da Costa K, Rai K, Craciunescu C, Parikh K, Mehedint M, Sanders L, et al.
J Biol Chem
. 2009 Nov;
285(2):1008-15.
PMID: 19889625
The development of fetal brain is influenced by nutrients such as docosahexaenoic acid (DHA, 22:6) and choline. Phosphatidylethanolamine-N-methyltransferase (PEMT) catalyzes the biosynthesis of phosphatidylcholine from phosphatidylethanolamine enriched in DHA and...
5.
Mehedint M, Niculescu M, Craciunescu C, Zeisel S
FASEB J
. 2009 Sep;
24(1):184-95.
PMID: 19752176
Maternal choline availability is essential for fetal neurogenesis. Choline deprivation (CD) causes hypomethylation of specific CpG islands in genes controlling cell cycling in fetal hippocampus. We now report that, in...