Cornelis van Breemen
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Explore the profile of Cornelis van Breemen including associated specialties, affiliations and a list of published articles.
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78
Citations
1333
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Recent Articles
1.
Fameli N, van Breemen C, Groschner K
Cell Calcium
. 2023 Nov;
117:102837.
PMID: 38011822
Spatio-temporal definition of Ca signals involves the assembly of signaling complexes within the nano-architecture of contact sites between the sarco/endoplasmic reticulum (SR/ER) and the plasma membrane (PM). While the requirement...
2.
van Breemen C, Fameli N, Groschner K
Int J Mol Sci
. 2022 Jan;
23(2).
PMID: 35055032
Nano-junctions between the endoplasmic reticulum and cytoplasmic surfaces of the plasma membrane and other organelles shape the spatiotemporal features of biological Ca signals. Herein, we propose that 2D Ca exchange...
3.
Cui J, Harris K, Raedschelders K, Hollander Z, Potts J, de Souza A, et al.
CJC Open
. 2021 May;
3(5):585-594.
PMID: 34027363
Background: Aortic dilation, stiffening, and dissection are common and potentially lethal complications of Marfan syndrome (MFS) and Loeys-Dietz syndrome (LDS), which involve abnormal transforming growth factor beta (TGF-β) signalling. The...
4.
Tehrani A, Cui J, Jones T, Hotova E, Castro M, Bernatchez P, et al.
Sci Rep
. 2020 Apr;
10(1):7154.
PMID: 32346027
Marfan syndrome (MFS) is a connective tissue disorder that results in aortic root widening and aneurysm if unmanaged. We have previously reported doxycycline, a nonselective matrix metalloproteinases (MMPs) inhibitor, to...
5.
Cui J, Lee L, Sheng X, Chu F, Gibson C, Aydinian T, et al.
Sci Rep
. 2019 Feb;
9(1):2071.
PMID: 30765726
Aortic aneurysm is the most life-threatening complication in Marfan syndrome (MFS) patients. Doxycycline, a nonselective matrix metalloproteinases inhibitor, was reported to improve the contractile function and elastic fiber structure and...
6.
Chohan H, Esfandiarei M, Arman D, Van Raamsdonk C, van Breemen C, Friedman J, et al.
PLoS One
. 2018 Dec;
13(12):e0208835.
PMID: 30571760
The fertility of men with neurofibromatosis 1 (NF1) is reduced. Despite this observation, gonadal function has not been examined in patients with NF1. In order to assess the role of...
7.
Fameli N, Mark Evans A, van Breemen C
Adv Exp Med Biol
. 2017 Sep;
993:321-342.
PMID: 28900922
In this chapter we examine the importance of cytoplasmic nanojunctions-nanometer scale appositions between organellar membranes including the molecular transporters therein-to the cell signaling machinery, with specific reference to Ca transport...
8.
Di Giuro C, Shrestha N, Malli R, Groschner K, van Breemen C, Fameli N
Pflugers Arch
. 2017 May;
469(10):1287-1299.
PMID: 28497275
We investigated the role of Na/ Ca exchange (NCX) in the refilling of endoplasmic reticulum (ER) Ca in vascular endothelial cells under various conditions of cell stimulation and plasma membrane...
9.
Gibson C, Nielsen C, Alex R, Cooper K, Farney M, Gaufin D, et al.
J Appl Physiol (1985)
. 2017 Apr;
123(1):147-160.
PMID: 28385916
Regular low-impact physical activity is generally allowed in patients with Marfan syndrome, a connective tissue disorder caused by heterozygous mutations in the fibrillin-1 gene. However, being above average in height...
10.
Ziomek G, van Breemen C, Esfandiarei M
J Vis Exp
. 2016 Jul;
(112).
PMID: 27403723
Maintenance of steady-state calcium (Ca(2+)) levels in the sarcoplasmic reticulum (SR) of vascular smooth muscle cells (VSMCs) is vital to their overall health. A significant portion of intracellular Ca(2+) content...