Connor A Olson
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Explore the profile of Connor A Olson including associated specialties, affiliations and a list of published articles.
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15
Citations
210
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Recent Articles
1.
Choe D, Olson C, Szubin R, Yang H, Sung J, Feist A, et al.
Nat Commun
. 2024 Mar;
15(1):2356.
PMID: 38490991
Machine learning applied to large compendia of transcriptomic data has enabled the decomposition of bacterial transcriptomes to identify independently modulated sets of genes, such iModulons represent specific cellular functions. The...
2.
Rychel K, Tan J, Patel A, Lamoureux C, Hefner Y, Szubin R, et al.
Cell Rep
. 2023 Sep;
42(9):113105.
PMID: 37713311
Relationships between the genome, transcriptome, and metabolome underlie all evolved phenotypes. However, it has proved difficult to elucidate these relationships because of the high number of variables measured. A recently...
3.
Anand A, Patel A, Chen K, Olson C, Phaneuf P, Lamoureux C, et al.
Nat Commun
. 2022 Jun;
13(1):3682.
PMID: 35760776
The bacterial respiratory electron transport system (ETS) is branched to allow condition-specific modulation of energy metabolism. There is a detailed understanding of the structural and biochemical features of respiratory enzymes;...
4.
Machado H, Seif Y, Sakoulas G, Olson C, Hefner Y, Anand A, et al.
Commun Biol
. 2021 Jun;
4(1):793.
PMID: 34172889
While microbiological resistance to vancomycin in Staphylococcus aureus is rare, clinical vancomycin treatment failures are common, and methicillin-resistant S. aureus (MRSA) strains isolated from patients after prolonged vancomycin treatment failure...
5.
Anand A, Olson C, Sastry A, Patel A, Szubin R, Yang L, et al.
Cell Rep
. 2021 Apr;
35(1):108961.
PMID: 33826886
Pyruvate dehydrogenase complex (PDC) functions as the main determinant of the respiro-fermentative balance because it converts pyruvate to acetyl-coenzyme A (CoA), which then enters the TCA (tricarboxylic acid cycle). PDC...
6.
Rajput A, Poudel S, Tsunemoto H, Meehan M, Szubin R, Olson C, et al.
Gigascience
. 2021 Jan;
10(1).
PMID: 33420779
Background: The evolving antibiotic-resistant behavior of health care-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) USA100 strains are of major concern. They are resistant to a broad class of antibiotics such as macrolides,...
7.
Poudel S, Tsunemoto H, Seif Y, Sastry A, Szubin R, Xu S, et al.
Proc Natl Acad Sci U S A
. 2020 Jul;
117(29):17228-17239.
PMID: 32616573
The ability of to infect many different tissue sites is enabled, in part, by its transcriptional regulatory network (TRN) that coordinates its gene expression to respond to different environments. We...
8.
Rajput A, Poudel S, Tsunemoto H, Meehan M, Szubin R, Olson C, et al.
Sci Data
. 2019 Dec;
6(1):322.
PMID: 31848353
Staphylococcus aureus strains have been continuously evolving resistance to numerous classes of antibiotics including methicillin, vancomycin, daptomycin and linezolid, compounding the enormous healthcare and economic burden of the pathogen. Cation-adjusted...
9.
Anand A, Chen K, Yang L, Sastry A, Olson C, Poudel S, et al.
Proc Natl Acad Sci U S A
. 2019 Nov;
116(50):25287-25292.
PMID: 31767748
Evolution fine-tunes biological pathways to achieve a robust cellular physiology. Two and a half billion years ago, rapidly rising levels of oxygen as a byproduct of blooming cyanobacterial photosynthesis resulted...
10.
Anand A, Chen K, Catoiu E, Sastry A, Olson C, Sandberg T, et al.
Mol Biol Evol
. 2019 Oct;
37(3):660-667.
PMID: 31651953
Oxidative stress is concomitant with aerobic metabolism. Thus, bacterial genomes encode elaborate mechanisms to achieve redox homeostasis. Here we report that the peroxide-sensing transcription factor, oxyR, is a common mutational...