Colin R Jefcoate
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Explore the profile of Colin R Jefcoate including associated specialties, affiliations and a list of published articles.
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57
Citations
839
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Recent Articles
31.
Tang Y, Scheef E, Wang S, Sorenson C, Marcus C, Jefcoate C, et al.
Blood
. 2008 Nov;
113(3):744-54.
PMID: 19005183
Reactive species derived from cell oxygenation processes play an important role in vascular homeostasis and the pathogenesis of many diseases including retinopathy of prematurity. We show that CYP1B1-deficient (CYP1B1(-/-)) mice...
32.
Halberg R, Larsen M, Elmergreen T, Ko A, Irving A, Clipson L, et al.
Cancer Res
. 2008 Sep;
68(18):7394-402.
PMID: 18794127
Cytochrome P450 1B1 (Cyp1b1) metabolism contributes to physiologic functions during embryogenesis but also to carcinogenic activation of polycyclic aromatic hydrocarbons (PAH). We generated Cyp1b1-deficient mice carrying the Min allele of...
33.
Jefcoate C, Wang S, Liu X
Methods Mol Biol
. 2008 Jun;
456:173-93.
PMID: 18516561
The mouse embryo fibroblast cell lines 3T3-L1 and C3H10T1/2 differentiate to adipocytes that exhibit similar insulin regulation of lipogenesis. These cell lines, however, differ appreciably in the processes that produce...
34.
Duan H, Jefcoate C
J Mol Endocrinol
. 2007 Jan;
38(1-2):159-79.
PMID: 17242178
cAMP stimulation of rodent steroidogenic cells produces two StAR transcripts, a major 3.5 kb and a minor 1.6 kb mRNA, differing only in their 3' untranslated regions (3' UTR). They...
35.
Yamazaki T, Matsuoka C, Gendou M, Izumi S, Zhao D, Artemenko I, et al.
Biochim Biophys Acta
. 2006 Oct;
1764(10):1561-7.
PMID: 17029976
Steroidogenic acute regulatory (StAR) protein is an important regulatory protein in steroidogenesis and rapidly undergoes proteolysis after import into the mitochondria. In this study, we determined the proteolytic cleavage sites...
36.
Jefcoate C
J Clin Invest
. 2006 Jul;
116(7):1832-5.
PMID: 16823483
Liver X receptors (LXRs) broadly limit cholesterol accumulation by regulating expression of genes involved in cholesterol efflux and storage. In this issue of the JCI, Cummins et al. report that...
37.
Tsuchiya Y, Nakajima M, Takagi S, Katoh M, Zheng W, Jefcoate C, et al.
J Biochem
. 2006 Mar;
139(3):527-34.
PMID: 16567417
Cytochrome P450 (CYP) 1B1, which catalyzes 17beta-estradiol 4-hydroxylation, is expressed in steroid-related tissues including ovary, testis, and adrenal gland. Generally, the expressions of steroidogenic CYPs are transcriptionally regulated by steroidogenic...
38.
Galvan N, Page T, Czuprynski C, Jefcoate C
Toxicol Appl Pharmacol
. 2005 Nov;
213(2):105-16.
PMID: 16307768
Polycyclic aromatic hydrocarbons (PAHs) are common environmental contaminants that are carcinogenic and immunosuppressive. Benzo(a)pyrene (BP) and 7,12-dimethylbenz(a)anthracene (DMBA) are two prototypic PAHs known to impair the cell-mediated and humoral immune...
39.
Hanlon P, Cimafranca M, Liu X, Cho Y, Jefcoate C
Toxicol Appl Pharmacol
. 2005 Aug;
207(1):39-58.
PMID: 16054899
C3H10T1/2 mouse embryo fibroblasts differentiate into adipocytes when stimulated by a standard hormonal mixture (IDMB). 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), via the aryl hydrocarbon receptor (AhR), inhibits induction of the key adipogenic gene...
40.
Zhao D, Duan H, Kim Y, Jefcoate C
J Steroid Biochem Mol Biol
. 2005 Jul;
96(2):155-73.
PMID: 16039847
The steroidogenic acute regulator (StAR) gene is transcribed to 1.6 kb and 3.5 kb mRNAs that differ only through the length of the 3'-untranslated region (3'-UTR). These forms result from...